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• W80931776 abstract "Back to table of contents Previous article Next article No AccessCortisol levels, immune status, and mood in homosexual men with and without HIV infectionPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.150.11.1674AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: Alteration in cortisol levels has been reported in HIV infection and may be related to levels of psychiatric distress and immune function. The goals of this study were to assess cortisol levels in subjects with HIV infection and to determine whether stress-related activation of the hypothalamic-pituitary-adrenal (HPA) axis results in compromised immune function. METHOD: As part of a longitudinal study, the authors assessed urinary free cortisol levels of HIV-positive and HIV-negative homosexual men at four time points during a period of 2 years. Subjects' scores on the Hamilton depression and anxiety rating scales, medical stage of HIV infection, and CD4+ and CD8+ cell counts were also assessed. Repeated measures analysis of variance was used to determine whether subjects' cortisol levels at the four time points differed according to their serological status. Pearson correlation coefficients were computed to examine the relationships among mood ratings, cortisol levels, medical stages, and cell counts. RESULTS: Cortisol levels did not differ significantly between the HIV-positive and the HIV-negative subjects and were not associated with stage of medical illness in HIV infection. An association between cortisol level and depressed and anxious mood was found only at the first assessment. Cortisol level was not associated with CD4+ cell count in either group of subjects. CONCLUSIONS: There were no significant elevations of cortisol levels in the HIV-infected subjects, nor was there consistent evidence for stress-related activation of the HPA axis in either the HIV-positive or the HIV-negative subjects. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byThe relationship of hair glucocorticoid levels to immunological and virological outcomes in a large cohort of combination antiretroviral therapy treated people living with HIV20 March 2022 | BMC Infectious Diseases, Vol. 22, No. 1Systematic review of sex differences in the relationship between hormones and depression in HIVPsychoneuroendocrinology, Vol. 138Sexual Orientation and Disclosure in Relation to Psychiatric Symptoms, Diurnal Cortisol, and Allostatic LoadPsychosomatic Medicine, Vol. 75, No. 2Psychoneuroendocrinology, Vol. 33, No. 1Journal of the American Dietetic Association, Vol. 104, No. 9HIV disease progression: depression, stress, and possible mechanismsBiological Psychiatry, Vol. 54, No. 3CNS Spectrums, Vol. 8, No. 1AIDS, Vol. 17, No. 1Physiologic Factors Contributing to a Transition in Oral Immunity among Mechanically Ventilated Adults25 July 2016 | Biological Research For Nursing, Vol. 3, No. 3Impact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDSJane Leserman, Ph.D., John M. Petitto, M.D., Robert N. Golden, M.D., Bradley N. Gaynes, M.D., Hongbin Gu, M.A., Diana O. Perkins, M.D., Susan G. Silva, Ph.D., James D. Folds, Ph.D., and Dwight L. Evans, M.D.1 August 2000 | American Journal of Psychiatry, Vol. 157, No. 8Journal of the American Dietetic Association, Vol. 100, No. 6Behavioral Medicine, Vol. 25, No. 4Cognitive-behavioral stress management buffers decreases in dehydroepiandrosterone sulfate (DHEA-S) and increases in the cortisol/DHEA-S ratio and reduces mood disturbance and perceived stress among HIV-seropositive menPsychoneuroendocrinology, Vol. 24, No. 5Psychosomatic Medicine, Vol. 60, No. 5Medicine, Vol. 75, No. 5Neuropathology and Applied Neurobiology, Vol. 21, No. 6Clinical Psychology Review, Vol. 14, No. 7 Volume 150Issue 11 November 1993Pages 1674-1678 Metrics PDF download History Published online 1 April 2006 Published in print 1 November 1993" @default.
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