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• W878607483 abstract "Tilorone and its congeners are immuno-modulatory agents demonstrating either immunostimulation or immunosuppression depending on the experiment, dosage, and timing. In common with all other immuno-modulatory agents adequately studied, tilorone is pleiotropic and often displays a biphasic activity pattern. The immunomodulatory effects of tilorone in man and all animal species other than rodents are produced in the absence of any detectable interferon induction. This chapter presents a comprehensive listing of the tilorone analogues and congeners synthesized at the Merrell-National Laboratories. Primary screening data have been included for this group of approximately 350 compounds. In addition, some independent synthetic chemistry publications have been briefly commented. The chapter discusses the general method of synthesis of the bis-basic substituted polycyclics. Bis-basic thioethers were synthesized via a multi-step reaction sequence involving the rearrangement of the dimethylthiocarbamoyl derivative of the dihydroxy intermediate followed by hydrolysis and alkylation with an aminoalkylchloride." @default.
• W878607483 created "2016-06-24" @default.
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• W878607483 date "1981-01-01" @default.
• W878607483 modified "2023-09-27" @default.
• W878607483 title "5 Tilorone and Related Bis-basic Substituted Polycyclic Aromatic and Heteroaromatic Compounds" @default.
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• W878607483 doi "https://doi.org/10.1016/s0079-6468(08)70319-9" @default.
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