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- W928196132 abstract "3 Introduction 4 The Circadian Rhythm 4 Nicotine and Immediate Early Genes 4 LTP and LTD 4 Egr1 5 Arc 7 Experiment 8 Methods 9 Subjects and Treatment 9 Probe Synthesis 9 In Situ Hybridization 10 OptiQuant Analysis 11 Statistical Analysis 11 Slide Organization 11 Results 14 Areas of the Brain Analyzed 14 General Trends 14 Significant Relationships 17 Discussion 20 Works Cited 30 The Effects of the Circadian Rhythm on Nicotine Induced Neuronal Plasticity 3 Abstract Nicotine is a widely popular addictive drug that alters neural circuits in the brain. The resulting neuronal plasticity is varied by the inherent circadian rhythm. During the circadian rhythm, high levels of melatonin are present in the dark phase and low levels in the light phase. Two immediate early genes, Activity-regulated cytoskeleton (Arc) and Early growth response 1 (Egr1), were used as markers to analyze the effects of nicotine-induced plasticity in the light and dark phases. The results showed lower levels of nicotine-induced neuronal plasticity (both Arc and Egr1 present in lower levels) in dark nicotine groups than in light nicotine groups. This is because nicotine-induced Arc and Egr1 levels are suppressed in the presence of melatonin. Melatonin inhibits long term potentiation (LTP), which is an essential mechanism for neuronal plasticity (Wang et al, 2005). Hence the circadian rhythm does affect nicotine-induced neuronal plasticity by suppressing the effects of nicotine in the dark. The Effects of the Circadian Rhythm on Nicotine Induced Neuronal Plasticity" @default.
- W928196132 created "2016-06-24" @default.
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- W928196132 date "2011-01-01" @default.
- W928196132 modified "2023-09-27" @default.
- W928196132 title "The Effects of the Circadian Rhythm on Nicotine-induced Neuronal Plasticity" @default.
- W928196132 hasPublicationYear "2011" @default.
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