Matches in Ubergraph for { ?s <http://www.w3.org/2004/02/skos/core#definition> ?o ?g. }
- BehaviorToBehavioralFeatureAssociation definition "An association between an mixture behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." @default.
- BehavioralExposure definition "A behavioral exposure is a factor relating to behavior impacting an individual." @default.
- BehavioralFeature definition "A phenotypic feature which is behavioral in nature." @default.
- BehavioralOutcome definition "An outcome resulting from an exposure event which is the manifestation of human behavior." @default.
- BiologicalProcess definition "One or more causally connected executions of molecular functions" @default.
- BiologicalProcessOrActivity definition "Either an individual molecular activity, or a collection of causally connected molecular activities in a biological system." @default.
- BioticExposure definition "An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses)." @default.
- Book definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." @default.
- Case definition "An individual (human) organism that has a patient role in some clinical context." @default.
- CaseToEntityAssociationMixin definition "An abstract association for use where the case is the subject" @default.
- CaseToPhenotypicFeatureAssociation definition "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype." @default.
- CellLineToDiseaseOrPhenotypicFeatureAssociation definition "An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype." @default.
- CellLineToEntityAssociationMixin definition "An relationship between a cell line and another entity" @default.
- CellularComponent definition "A location in or around a cell" @default.
- ChemicalAffectsGeneAssociation definition "Describes an effect that a chemical has on a gene or gene product (e.g. an impact of on its abundance, activity, localization, processing, expression, etc.)" @default.
- ChemicalEntity definition "A chemical entity is a physical entity that pertains to chemistry or biochemistry." @default.
- ChemicalEntityOrGeneOrGeneProduct definition "A union of chemical entities and children, and gene or gene product. This mixin is helpful to use when searching across chemical entities that must include genes and their children as chemical entities." @default.
- ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation definition "A regulatory relationship between two genes" @default.
- ChemicalEntityOrProteinOrPolypeptide definition "A union of chemical entities and children, and protein and polypeptide. This mixin is helpful to use when searching across chemical entities that must include genes and their children as chemical entities." @default.
- ChemicalEntityToEntityAssociationMixin definition "An interaction between a chemical entity and another entity" @default.
- ChemicalExposure definition "A chemical exposure is an intake of a particular chemical entity." @default.
- ChemicalGeneInteractionAssociation definition "describes a physical interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)" @default.
- ChemicalMixture definition "A chemical mixture is a chemical entity composed of two or more molecular entities." @default.
- ChemicalToChemicalAssociation definition "A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another." @default.
- ChemicalToChemicalDerivationAssociation definition "A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction: IF R has-input C1 AND R has-output C2 AND R enabled-by P AND R type Reaction THEN C1 derives-into C2 <<catalyst qualifier P>>" @default.
- ChemicalToDiseaseOrPhenotypicFeatureAssociation definition "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype." @default.
- ChemicalToEntityAssociationMixin definition "An interaction between a chemical entity and another entity" @default.
- ChemicalToGeneAssociation definition "An interaction between a chemical entity and a gene or gene product." @default.
- ChemicalToPathwayAssociation definition "An interaction between a chemical entity and a biological process or pathway." @default.
- ClinicalAttribute definition "Attributes relating to a clinical manifestation" @default.
- ClinicalCourse definition "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual" @default.
- ClinicalEntity definition "Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities" @default.
- ClinicalFinding definition "this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations." @default.
- ClinicalMeasurement definition "A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot." @default.
- ClinicalModifier definition "Used to characterize and specify the phenotypic abnormalities defined in the phenotypic abnormality sub-ontology, with respect to severity, laterality, and other aspects" @default.
- Cohort definition "A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time." @default.
- ComplexChemicalExposure definition "A complex chemical exposure is an intake of a chemical mixture (e.g. gasoline), other than a drug." @default.
- ComplexMolecularMixture definition "A complex molecular mixture is a chemical mixture composed of two or more molecular entities with unknown concentration and stoichiometry." @default.
- ConfidenceLevel definition "Level of confidence in a statement" @default.
- ContributorAssociation definition "Any association between an entity (such as a publication) and various agents that contribute to its realisation" @default.
- Dataset definition "an item that refers to a collection of data from a data source." @default.
- DatasetDistribution definition "an item that holds distribution level information about a dataset." @default.
- DatasetSummary definition "an item that holds summary level information about a dataset." @default.
- DatasetVersion definition "an item that holds version level information about a dataset." @default.
- Device definition "A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment" @default.
- Discovery%20%26%20Development%20Phase definition "Discovery & Development Phase. Discovery involves researchers finding new possibilities for medication through testing molecular compounds, noting unexpected effects from existing treatments, or the creation of new technology that allows novel ways of targeting medical products to sites in the body. Drug development occurs after researchers identify potential compounds for experiments." @default.
- Disease definition "A disorder of structure or function, especially one that produces specific signs, phenotypes or symptoms or that affects a specific location and is not simply a direct result of physical injury. A disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism." @default.
- DiseaseOrPhenotypicFeature definition "Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate. distinct, others such as MESH conflate. Please see definitions of phenotypic feature and disease in this model for their independent descriptions. This class is helpful to enforce domains and ranges that may involve either a disease or a phenotypic feature." @default.
- DiseaseOrPhenotypicFeatureExposure definition "A disease or phenotypic feature state, when viewed as an exposure, represents an precondition, leading to or influencing an outcome, e.g. HIV predisposing an individual to infections; a relative deficiency of skin pigmentation predisposing an individual to skin cancer." @default.
- DiseaseOrPhenotypicFeatureOutcome definition "Physiological outcomes resulting from an exposure event which is the manifestation of a disease or other characteristic phenotype." @default.
- DiseaseOrPhenotypicFeatureToLocationAssociation definition "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site." @default.
- DiseaseToExposureEventAssociation definition "An association between an exposure event and a disease." @default.
- DiseaseToPhenotypicFeatureAssociation definition "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way." @default.
- Drug definition "A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" @default.
- DrugExposure definition "A drug exposure is an intake of a particular drug." @default.
- DrugToEntityAssociationMixin definition "An interaction between a drug and another entity" @default.
- DrugToGeneAssociation definition "An interaction between a drug and a gene or gene product." @default.
- DrugToGeneInteractionExposure definition "drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome." @default.
- Entity definition "Root Biolink Model class for all things and informational relationships, real or imagined." @default.
- EntityToDiseaseAssociationMixin definition "mixin class for any association whose object (target node) is a disease" @default.
- EntityToExposureEventAssociationMixin definition "An association between some entity and an exposure event." @default.
- EntityToFeatureOrDiseaseQualifiersMixin definition "Qualifiers for entity to disease or phenotype associations." @default.
- EntityToOutcomeAssociationMixin definition "An association between some entity and an outcome" @default.
- EnvironmentalExposure definition "A environmental exposure is a factor relating to abiotic processes in the environment including sunlight (UV-B), atmospheric (heat, cold, general pollution) and water-born contaminants." @default.
- EpidemiologicalOutcome definition "An epidemiological outcome, such as societal disease burden, resulting from an exposure event." @default.
- Event definition "Something that happens at a given place and time." @default.
- EvidenceType definition "Class of evidence that supports an association" @default.
- Exon definition "A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing." @default.
- ExonToTranscriptRelationship definition "A transcript is formed from multiple exons" @default.
- ExposureEvent definition "A (possibly time bounded) incidence of a feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes" @default.
- ExposureEventToOutcomeAssociation definition "An association between an exposure event and an outcome." @default.
- ExposureEventToPhenotypicFeatureAssociation definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." @default.
- FDA%20Accelerated%20Approval definition "When studying a new drug, it can sometimes take many years to learn whether a drug actually provides a real effect on how a patient survives, feels, or functions. A positive therapeutic effect that is clinically meaningful in the context of a given disease is known as “clinical benefit”. Mindful of the fact that it may take an extended period of time to measure a drug’s intended clinical benefit, in 1992 FDA instituted the Accelerated Approval regulations. These regulations allowed drugs for serious conditions that filled an unmet medical need to be approved based on a surrogate endpoint. Using a surrogate endpoint enabled the FDA to approve these drugs faster. For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/accelerated-approval" @default.
- FDA%20Breakthrough%20Therapy definition "Breakthrough Therapy designation is a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint(s). For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/breakthrough-therapy" @default.
- FDA%20Clinical%20Research%20Phase definition "Clinical Research Phase. Clinical research involves trials of the drug on people, and it is one of the most involved stages in the drug development and approval process. Clinical trials must answer specific questions and follow a protocol determined by the drug researcher or manufacturer." @default.
- FDA%20Clinical%20Research%20Phase%201 definition "In the FDA Clinical Research Phase, the Clinical Research Phase 1 involves 20 – 100 study participants and lasts several months. This phase is used to determine the safety and dosage of the drug, and about 70% of these drugs move on to the next clinical research phase." @default.
- FDA%20Clinical%20Research%20Phase%202 definition "In the FDA Clinical Research Phase, the Clinical Research Phase 2 involves up to several hundred people, who must have the disease or condition the drug supposes to treat. This phase can last from a few months to two years, and its purpose is to monitor the efficacy of the drug, as well as note side effects that may occur." @default.
- FDA%20Clinical%20Research%20Phase%203 definition "In the FDA Clinical Research Phase, the Clinical Research Phase 3 involves 300 – 3000 volunteers and can last up to four years. It is used to continue monitoring the efficacy of the drug, as well as exploring any longer-term adverse reactions." @default.
- FDA%20Clinical%20Research%20Phase%204 definition "In the FDA Clinical Research Phase, the Clinical Research Phase 4 involves several thousands of volunteers who have the disease or condition and continues to monitor safety and efficacy. If a drug passes this phase, it goes on to FDA review." @default.
- FDA%20Fast%20Track definition "Fast track is a process designed to facilitate the development, and expedite the review of drugs to treat serious conditions and fill an unmet medical need. The purpose is to get important new drugs to the patient earlier. Fast Track addresses a broad range of serious conditions. For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/fast-track" @default.
- FDA%20Post-Market%20Safety%20Monitoring definition "FDA Post-Market Safety Monitoring. The last phase of drug approval is an ongoing one while the drug is on the marketplace. If a developer wants to change anything about the drug formulation or approve it for a new use, they must apply with the FDA. The FDA also frequently reviews the drug’s advertising and its manufacturing facility to make sure everything involved in its creation and marketing is in compliance with regulations." @default.
- FDA%20Priority%20Review definition "Prior to approval, each drug marketed in the United States must go through a detailed FDA review process. In 1992, under the Prescription Drug User Act (PDUFA), FDA agreed to specific goals for improving the drug review time and created a two-tiered system of review times – Standard Review and Priority Review. A Priority Review designation means FDA’s goal is to take action on an application within 6 months (compared to 10 months under standard review). For more information https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/priority-review" @default.
- FDA%20Review%20Phase%204 definition "FDA Review" @default.
- FDA_approval_status definition "" @default.
- FDA_approval_status_enum definition "" @default.
- Food definition "A substance consumed by a living organism as a source of nutrition" @default.
- FrequencyQualifierMixin definition "Qualifier for frequency type associations" @default.
- FunctionalAssociation definition "An association between a macromolecular machine mixin (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed." @default.
- Gene definition "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene locus may include regulatory regions, transcribed regions and/or other functional sequence regions." @default.
- GeneExpressionMixin definition "Observed gene expression intensity, context (site, stage) and associated phenotypic status within which the expression occurs." @default.
- GeneFamily definition "any grouping of multiple genes or gene products related by common descent" @default.
- GeneGroupingMixin definition "any grouping of multiple genes or gene products" @default.
- GeneOrGeneProduct definition "A union of gene loci or gene products. Frequently an identifier for one will be used as proxy for another" @default.
- GeneProductIsoformMixin definition "This is an abstract class that can be mixed in with different kinds of gene products to indicate that the gene product is intended to represent a specific isoform rather than a canonical or reference or generic product. The designation of canonical or reference may be arbitrary, or it may represent the superclass of all isoforms." @default.
- GeneProductMixin definition "The functional molecular product of a single gene locus. Gene products are either proteins or functional RNA molecules." @default.
- GeneRegulatoryRelationship definition "A regulatory relationship between two genes" @default.
- GeneToExpressionSiteAssociation definition "An association between a gene and a gene expression site, possibly qualified by stage/timing info." @default.
- GeneToGeneAssociation definition "abstract parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction." @default.
- GeneToGeneCoexpressionAssociation definition "Indicates that two genes are co-expressed, generally under the same conditions." @default.
- GeneToGeneHomologyAssociation definition "A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)" @default.