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- NCIT_C100101 IAO_0000115 "An immunoconjugate that consists of a humanized IgG1 antibody K7153A against the cell-surface antigen CD37 and covalently linked via the uncleavable, maleimide-derived thioether-based linker SMCC to the maytansinoid DM1, with potential pro-apoptotic and cytotoxic activities. Upon administration of naratuximab emtansine, the antibody moiety of IMGN529 binds to CD37 on tumor B-cells and induces an antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), thereby showing pro-apoptotic activity. In addition, after the internalization of this agent and lysosomal degradation, the DM1 moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and eventually causing cell death in CD37-positive B-cells. CD37, a transmembrane glycoprotein, is overexpressed in B-cell malignancies. Compared to reducible, cleavable linkers, the non-reducible SMCC linker shows increased stability in plasma." @default.
- NCIT_C100101 NCIT_A32 NCIT_C1909 @default.
- NCIT_C100101 NCIT_NHC0 "C100101" @default.
- NCIT_C100101 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C100101 NCIT_P107 "Naratuximab Emtansine" @default.
- NCIT_C100101 NCIT_P108 "Naratuximab Emtansine" @default.
- NCIT_C100101 NCIT_P207 "C3639093" @default.
- NCIT_C100101 NCIT_P210 "1607824-64-5" @default.
- NCIT_C100101 NCIT_P319 "WE1X5A83B9" @default.
- NCIT_C100101 NCIT_P322 "CTRP" @default.
- NCIT_C100101 NCIT_P322 "FDA" @default.
- NCIT_C100101 NCIT_P322 "GDC" @default.
- NCIT_C100101 NCIT_P329 "727107" @default.
- NCIT_C100101 NCIT_P330 "727107" @default.
- NCIT_C100101 NCIT_P375 "Anti-CD37 Antibody-Drug Conjugate IMGN529" @default.
- NCIT_C100101 NCIT_P375 "Naratuximab Emtansine" @default.
- NCIT_C100101 NCIT_P399 "727107" @default.
- NCIT_C100101 normalizedInformationContent "100" @default.
- NCIT_C100101 referenceCount "1" @default.
- NCIT_C100101 hasExactSynonym "IMGN529" @default.
- NCIT_C100101 hasExactSynonym "MP 529" @default.
- NCIT_C100101 hasExactSynonym "MP-529" @default.
- NCIT_C100101 hasExactSynonym "MP529" @default.
- NCIT_C100101 hasExactSynonym "NARATUXIMAB EMTANSINE" @default.
- NCIT_C100101 hasExactSynonym "Naratuximab Emtansine" @default.
- NCIT_C100101 inSubset NCIT_C116977 @default.
- NCIT_C100101 inSubset NCIT_C116978 @default.
- NCIT_C100101 inSubset NCIT_C128784 @default.
- NCIT_C100101 inSubset NCIT_C157711 @default.
- NCIT_C100101 inSubset NCIT_C157712 @default.
- NCIT_C100101 inSubset NCIT_C176424 @default.
- NCIT_C100101 inSubset NCIT_C177537 @default.
- NCIT_C100101 inSubset NCIT_C63923 @default.
- NCIT_C100101 type Class @default.
- NCIT_C100101 isDefinedBy ncit.owl @default.
- NCIT_C100101 label "Naratuximab Emtansine" @default.
- NCIT_C100101 subClassOf NCIT_C100101 @default.
- NCIT_C100101 subClassOf NCIT_C129821 @default.
- NCIT_C100101 subClassOf NCIT_C129823 @default.
- NCIT_C100101 subClassOf NCIT_C1512 @default.
- NCIT_C100101 subClassOf NCIT_C1908 @default.
- NCIT_C100101 subClassOf NCIT_C1909 @default.
- NCIT_C100101 subClassOf NCIT_C274 @default.
- NCIT_C100101 subClassOf NCIT_C307 @default.
- NCIT_C100101 subClassOf NCIT_C308 @default.