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- NCIT_C1010 IAO_0000115 "A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of prostacyclin (prostaglandin I2; PGI2) and prevents intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. An elevated level of PGI2 prevents aggregation of platelets; subsequently it decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis." @default.
- NCIT_C1010 NCIT_NHC0 "C1010" @default.
- NCIT_C1010 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1010 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1010 NCIT_P108 "Nafazatrom" @default.
- NCIT_C1010 NCIT_P207 "C0053025" @default.
- NCIT_C1010 NCIT_P210 "59040-30-1" @default.
- NCIT_C1010 NCIT_P319 "K94216221B" @default.
- NCIT_C1010 NCIT_P322 "FDA" @default.
- NCIT_C1010 NCIT_P329 "39508" @default.
- NCIT_C1010 NCIT_P330 "39508" @default.
- NCIT_C1010 NCIT_P350 "C16H16N2O2" @default.
- NCIT_C1010 NCIT_P366 "Nafazatrom" @default.
- NCIT_C1010 NCIT_P399 "39508" @default.
- NCIT_C1010 normalizedInformationContent "100" @default.
- NCIT_C1010 referenceCount "1" @default.
- NCIT_C1010 hasExactSynonym "1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-one" @default.
- NCIT_C1010 hasExactSynonym "3H-pyrazol-3-one,2,4-dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethyl)" @default.
- NCIT_C1010 hasExactSynonym "Bay g 6575" @default.
- NCIT_C1010 hasExactSynonym "Bay-g 6575" @default.
- NCIT_C1010 hasExactSynonym "NAFAZATROM" @default.
- NCIT_C1010 hasExactSynonym "Nafazatrom" @default.
- NCIT_C1010 inSubset NCIT_C176424 @default.
- NCIT_C1010 inSubset NCIT_C63923 @default.
- NCIT_C1010 type Class @default.
- NCIT_C1010 isDefinedBy ncit.owl @default.
- NCIT_C1010 label "Nafazatrom" @default.
- NCIT_C1010 subClassOf NCIT_C1010 @default.
- NCIT_C1010 subClassOf NCIT_C1908 @default.
- NCIT_C1010 subClassOf NCIT_C1909 @default.
- NCIT_C1010 subClassOf NCIT_C29750 @default.
- NCIT_C1010 subClassOf NCIT_C78275 @default.