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- NCIT_C1015 IAO_0000115 "A microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage and bone marrow stem cell as well as stimulates release of interleukin-1 and -2, thus further enhances its antitumor activity." @default.
- NCIT_C1015 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1015 NCIT_NHC0 "C1015" @default.
- NCIT_C1015 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1015 NCIT_P106 "Antibiotic" @default.
- NCIT_C1015 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1015 NCIT_P108 "Ubenimex" @default.
- NCIT_C1015 NCIT_P175 "265489" @default.
- NCIT_C1015 NCIT_P207 "C0053355" @default.
- NCIT_C1015 NCIT_P210 "58970-76-6" @default.
- NCIT_C1015 NCIT_P319 "I0J33N5627" @default.
- NCIT_C1015 NCIT_P322 "FDA" @default.
- NCIT_C1015 NCIT_P322 "GDC" @default.
- NCIT_C1015 NCIT_P329 "39164" @default.
- NCIT_C1015 NCIT_P330 "39164" @default.
- NCIT_C1015 NCIT_P350 "C16H24N2O4" @default.
- NCIT_C1015 NCIT_P366 "Ubenimex" @default.
- NCIT_C1015 NCIT_P375 "Ubenimex" @default.
- NCIT_C1015 NCIT_P399 "39164" @default.
- NCIT_C1015 normalizedInformationContent "100" @default.
- NCIT_C1015 referenceCount "1" @default.
- NCIT_C1015 hasExactSynonym "Bestatin" @default.
- NCIT_C1015 hasExactSynonym "L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-" @default.
- NCIT_C1015 hasExactSynonym "N-[(2S,3R)-4-phenyl-3-amino-2-hydroxybutyryl]-L-leucine" @default.
- NCIT_C1015 hasExactSynonym "NK 421" @default.
- NCIT_C1015 hasExactSynonym "UBENIMEX" @default.
- NCIT_C1015 hasExactSynonym "Ubenimex" @default.
- NCIT_C1015 hasExactSynonym "[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine" @default.
- NCIT_C1015 hasExactSynonym "[S-(R*,S*)]-N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine" @default.
- NCIT_C1015 inSubset NCIT_C128784 @default.
- NCIT_C1015 inSubset NCIT_C157711 @default.
- NCIT_C1015 inSubset NCIT_C157712 @default.
- NCIT_C1015 inSubset NCIT_C176424 @default.
- NCIT_C1015 inSubset NCIT_C177537 @default.
- NCIT_C1015 inSubset NCIT_C63923 @default.
- NCIT_C1015 type Class @default.
- NCIT_C1015 isDefinedBy ncit.owl @default.
- NCIT_C1015 label "Ubenimex" @default.
- NCIT_C1015 subClassOf NCIT_C1015 @default.
- NCIT_C1015 subClassOf NCIT_C1908 @default.
- NCIT_C1015 subClassOf NCIT_C1909 @default.
- NCIT_C1015 subClassOf NCIT_C2139 @default.
- NCIT_C1015 subClassOf NCIT_C308 @default.