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- NCIT_C101521 IAO_0000115 "An immunoglobulin G1 lambda monoclonal antibody directed against the Notch ligand delta-like 4 (DLL4) with potential antineoplastic activity. Anti-DLL4 monoclonal antibody MEDI0639 specifically binds to DLL4 and prevents its interaction with Notch receptors, thereby inhibiting Notch-mediated signaling and gene transcription, which may block tumor angiogenesis and eventually the inhibition of tumor cell growth. Activation of Notch receptors by DLL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated to the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development. The expression of DLL4 is highly restricted to the vascular endothelium; DLL4/Notch signaling is required for the development of functional tumor blood vessels." @default.
- NCIT_C101521 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101521 NCIT_A7 NCIT_C90319 @default.
- NCIT_C101521 NCIT_NHC0 "C101521" @default.
- NCIT_C101521 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C101521 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101521 NCIT_P107 "Anti-DLL4 Monoclonal Antibody MEDI0639" @default.
- NCIT_C101521 NCIT_P108 "Anti-DLL4 Monoclonal Antibody MEDI0639" @default.
- NCIT_C101521 NCIT_P208 "CL435778" @default.
- NCIT_C101521 NCIT_P319 "LPT9GX4OUB" @default.
- NCIT_C101521 NCIT_P322 "CTRP" @default.
- NCIT_C101521 NCIT_P322 "FDA" @default.
- NCIT_C101521 NCIT_P322 "GDC" @default.
- NCIT_C101521 NCIT_P329 "732226" @default.
- NCIT_C101521 NCIT_P330 "732226" @default.
- NCIT_C101521 NCIT_P375 "Anti-DLL4 Monoclonal Antibody MEDI0639" @default.
- NCIT_C101521 NCIT_P399 "732226" @default.
- NCIT_C101521 NCIT_R124 NCIT_C17710 @default.
- NCIT_C101521 NCIT_R124 NCIT_C17828 @default.
- NCIT_C101521 NCIT_R124 NCIT_C18219 @default.
- NCIT_C101521 NCIT_R124 NCIT_C19986 @default.
- NCIT_C101521 NCIT_R124 NCIT_C40474 @default.
- NCIT_C101521 normalizedInformationContent "100" @default.
- NCIT_C101521 referenceCount "1" @default.
- NCIT_C101521 hasExactSynonym "Anti-DLL4 Monoclonal Antibody MEDI0639" @default.
- NCIT_C101521 hasExactSynonym "MEDI-0639" @default.
- NCIT_C101521 hasExactSynonym "MEDI0639" @default.
- NCIT_C101521 inSubset NCIT_C116977 @default.
- NCIT_C101521 inSubset NCIT_C116978 @default.
- NCIT_C101521 inSubset NCIT_C128784 @default.
- NCIT_C101521 inSubset NCIT_C157711 @default.
- NCIT_C101521 inSubset NCIT_C157712 @default.
- NCIT_C101521 inSubset NCIT_C176424 @default.
- NCIT_C101521 inSubset NCIT_C177537 @default.
- NCIT_C101521 inSubset NCIT_C63923 @default.
- NCIT_C101521 type Class @default.
- NCIT_C101521 isDefinedBy ncit.owl @default.
- NCIT_C101521 label "Anti-DLL4 Monoclonal Antibody MEDI0639" @default.
- NCIT_C101521 subClassOf NCIT_C101521 @default.
- NCIT_C101521 subClassOf NCIT_C129821 @default.
- NCIT_C101521 subClassOf NCIT_C129822 @default.
- NCIT_C101521 subClassOf NCIT_C1908 @default.
- NCIT_C101521 subClassOf NCIT_C1909 @default.
- NCIT_C101521 subClassOf NCIT_C20401 @default.
- NCIT_C101521 subClassOf NCIT_C274 @default.
- NCIT_C101521 subClassOf NCIT_C307 @default.
- NCIT_C101521 subClassOf NCIT_C308 @default.