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- NCIT_C101523 IAO_0000115 "A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug TH-4000 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated. As a result, this agent inhibits cellular proliferation and differentiation of tumor cells overexpressing HER kinases, which belong to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity." @default.
- NCIT_C101523 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101523 NCIT_NHC0 "C101523" @default.
- NCIT_C101523 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101523 NCIT_P107 "Hypoxia-activated Prodrug TH-4000" @default.
- NCIT_C101523 NCIT_P108 "Hypoxia-activated Prodrug TH-4000" @default.
- NCIT_C101523 NCIT_P208 "CL435780" @default.
- NCIT_C101523 NCIT_P322 "CTRP" @default.
- NCIT_C101523 NCIT_P322 "GDC" @default.
- NCIT_C101523 NCIT_P329 "732241" @default.
- NCIT_C101523 NCIT_P330 "732241" @default.
- NCIT_C101523 NCIT_P375 "Hypoxia-activated Prodrug TH-4000" @default.
- NCIT_C101523 NCIT_P399 "732241" @default.
- NCIT_C101523 normalizedInformationContent "100" @default.
- NCIT_C101523 referenceCount "1" @default.
- NCIT_C101523 hasExactSynonym "Hypoxia-activated Prodrug TH-4000" @default.
- NCIT_C101523 hasExactSynonym "Hypoxin" @default.
- NCIT_C101523 hasExactSynonym "PR610" @default.
- NCIT_C101523 hasExactSynonym "TH-4000" @default.
- NCIT_C101523 inSubset NCIT_C116977 @default.
- NCIT_C101523 inSubset NCIT_C116978 @default.
- NCIT_C101523 inSubset NCIT_C128784 @default.
- NCIT_C101523 inSubset NCIT_C157711 @default.
- NCIT_C101523 inSubset NCIT_C157712 @default.
- NCIT_C101523 inSubset NCIT_C176424 @default.
- NCIT_C101523 inSubset NCIT_C177537 @default.
- NCIT_C101523 type Class @default.
- NCIT_C101523 isDefinedBy ncit.owl @default.
- NCIT_C101523 label "Hypoxia-activated Prodrug TH-4000" @default.
- NCIT_C101523 subClassOf NCIT_C101523 @default.
- NCIT_C101523 subClassOf NCIT_C1404 @default.
- NCIT_C101523 subClassOf NCIT_C1908 @default.
- NCIT_C101523 subClassOf NCIT_C1909 @default.
- NCIT_C101523 subClassOf NCIT_C1967 @default.
- NCIT_C101523 subClassOf NCIT_C471 @default.