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- NCIT_C101524 IAO_0000115 "An antibody-drug conjugate (ADC) containing a monoclonal antibody directed against guanylyl cyclase C (GCC or GUCY2C) conjugated to monomethylauristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. The monoclonal antibody moiety of indusatumab vedotin selectively binds to GCC, a transmembrane receptor normally found on intestinal cells and dopamine neurons in the brain, but is also overexpressed on the surface of gastrointestinal cancers. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis in GCC-expressing tumor cells." @default.
- NCIT_C101524 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101524 NCIT_A7 NCIT_C123877 @default.
- NCIT_C101524 NCIT_NHC0 "C101524" @default.
- NCIT_C101524 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101524 NCIT_P107 "Indusatumab Vedotin" @default.
- NCIT_C101524 NCIT_P108 "Indusatumab Vedotin" @default.
- NCIT_C101524 NCIT_P208 "CL435781" @default.
- NCIT_C101524 NCIT_P210 "1514889-12-3" @default.
- NCIT_C101524 NCIT_P319 "3F0FR4W3H8" @default.
- NCIT_C101524 NCIT_P322 "CTRP" @default.
- NCIT_C101524 NCIT_P322 "FDA" @default.
- NCIT_C101524 NCIT_P322 "GDC" @default.
- NCIT_C101524 NCIT_P329 "732254" @default.
- NCIT_C101524 NCIT_P330 "732254" @default.
- NCIT_C101524 NCIT_P375 "Anti-GCC Antibody-Drug Conjugate MLN0264" @default.
- NCIT_C101524 NCIT_P375 "Indusatumab Vedotin" @default.
- NCIT_C101524 NCIT_P399 "732254" @default.
- NCIT_C101524 normalizedInformationContent "100" @default.
- NCIT_C101524 referenceCount "1" @default.
- NCIT_C101524 hasExactSynonym "INDUSATUMAB VEDOTIN" @default.
- NCIT_C101524 hasExactSynonym "Indusatumab Vedotin" @default.
- NCIT_C101524 hasExactSynonym "MLN0264" @default.
- NCIT_C101524 inSubset NCIT_C116977 @default.
- NCIT_C101524 inSubset NCIT_C116978 @default.
- NCIT_C101524 inSubset NCIT_C128784 @default.
- NCIT_C101524 inSubset NCIT_C157711 @default.
- NCIT_C101524 inSubset NCIT_C157712 @default.
- NCIT_C101524 inSubset NCIT_C176424 @default.
- NCIT_C101524 inSubset NCIT_C177537 @default.
- NCIT_C101524 inSubset NCIT_C63923 @default.
- NCIT_C101524 type Class @default.
- NCIT_C101524 isDefinedBy ncit.owl @default.
- NCIT_C101524 label "Indusatumab Vedotin" @default.
- NCIT_C101524 subClassOf NCIT_C101524 @default.
- NCIT_C101524 subClassOf NCIT_C129821 @default.
- NCIT_C101524 subClassOf NCIT_C129823 @default.
- NCIT_C101524 subClassOf NCIT_C1512 @default.
- NCIT_C101524 subClassOf NCIT_C1908 @default.
- NCIT_C101524 subClassOf NCIT_C1909 @default.
- NCIT_C101524 subClassOf NCIT_C274 @default.
- NCIT_C101524 subClassOf NCIT_C307 @default.
- NCIT_C101524 subClassOf NCIT_C308 @default.