Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C101538> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- NCIT_C101538 IAO_0000115 "A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, molibresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth." @default.
- NCIT_C101538 NCIT_A32 NCIT_C1909 @default.
- NCIT_C101538 NCIT_A7 NCIT_C106463 @default.
- NCIT_C101538 NCIT_A7 NCIT_C21376 @default.
- NCIT_C101538 NCIT_A7 NCIT_C92704 @default.
- NCIT_C101538 NCIT_A7 NCIT_C97399 @default.
- NCIT_C101538 NCIT_NHC0 "C101538" @default.
- NCIT_C101538 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C101538 NCIT_P107 "Molibresib" @default.
- NCIT_C101538 NCIT_P108 "Molibresib" @default.
- NCIT_C101538 NCIT_P207 "C2975231" @default.
- NCIT_C101538 NCIT_P210 "1260907-17-2" @default.
- NCIT_C101538 NCIT_P319 "5QIO6SRZ2R" @default.
- NCIT_C101538 NCIT_P322 "CTRP" @default.
- NCIT_C101538 NCIT_P322 "FDA" @default.
- NCIT_C101538 NCIT_P322 "GDC" @default.
- NCIT_C101538 NCIT_P329 "733799" @default.
- NCIT_C101538 NCIT_P330 "733799" @default.
- NCIT_C101538 NCIT_P375 "Molibresib" @default.
- NCIT_C101538 NCIT_P399 "733799" @default.
- NCIT_C101538 normalizedInformationContent "100" @default.
- NCIT_C101538 referenceCount "1" @default.
- NCIT_C101538 hasExactSynonym "GSK-525762A" @default.
- NCIT_C101538 hasExactSynonym "GSK525762" @default.
- NCIT_C101538 hasExactSynonym "I-BET 762" @default.
- NCIT_C101538 hasExactSynonym "MOLIBRESIB" @default.
- NCIT_C101538 hasExactSynonym "Molibresib" @default.
- NCIT_C101538 inSubset NCIT_C116977 @default.
- NCIT_C101538 inSubset NCIT_C116978 @default.
- NCIT_C101538 inSubset NCIT_C128784 @default.
- NCIT_C101538 inSubset NCIT_C157711 @default.
- NCIT_C101538 inSubset NCIT_C157712 @default.
- NCIT_C101538 inSubset NCIT_C176424 @default.
- NCIT_C101538 inSubset NCIT_C177537 @default.
- NCIT_C101538 inSubset NCIT_C63923 @default.
- NCIT_C101538 type Class @default.
- NCIT_C101538 isDefinedBy ncit.owl @default.
- NCIT_C101538 label "Molibresib" @default.
- NCIT_C101538 subClassOf NCIT_C101538 @default.
- NCIT_C101538 subClassOf NCIT_C128462 @default.
- NCIT_C101538 subClassOf NCIT_C129824 @default.
- NCIT_C101538 subClassOf NCIT_C1908 @default.
- NCIT_C101538 subClassOf NCIT_C1909 @default.
- NCIT_C101538 subClassOf NCIT_C2189 @default.
- NCIT_C101538 subClassOf NCIT_C274 @default.