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- NCIT_C1022 IAO_0000115 "An orally available antimetabolite composed of the 1-ethoxymethyl derivative of 5-fluorouracil (5-FU) and the dihydropyrimidine dehydrogenase (DPYD) inhibitor 3-cyano-2,6-dihydroxypyridine (CNDP) in a 1:1 molar ratio, with antineoplastic activity. Upon administration, the prodrug emitefur is converted into 5-FU, while CNDP prevents the degradation of 5-FU by inhibiting DPYD and thereby prolonging the half-life of 5-FU. This increases 5-FU's concentration and thus its antitumor activity through inhibition of DNA and RNA synthesis, as well as inhibition of thymidylate synthase activity. In addition, by inhibiting the formation of 5-FU metabolites, some toxic effects associated with these metabolites may be reduced. DPYD is the rate-limiting enzyme in the catabolism of 5-FU." @default.
- NCIT_C1022 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1022 NCIT_NHC0 "C1022" @default.
- NCIT_C1022 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1022 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1022 NCIT_P108 "Emitefur" @default.
- NCIT_C1022 NCIT_P207 "C0053902" @default.
- NCIT_C1022 NCIT_P210 "110690-43-2" @default.
- NCIT_C1022 NCIT_P319 "9I50NF4AQ2" @default.
- NCIT_C1022 NCIT_P322 "FDA" @default.
- NCIT_C1022 NCIT_P322 "GDC" @default.
- NCIT_C1022 NCIT_P325 "An anticancer drug that belongs to the family of drugs called antimetabolites." @default.
- NCIT_C1022 NCIT_P350 "C28H19FN4O8" @default.
- NCIT_C1022 NCIT_P366 "Emitefur" @default.
- NCIT_C1022 NCIT_P375 "Emitefur" @default.
- NCIT_C1022 normalizedInformationContent "100" @default.
- NCIT_C1022 referenceCount "1" @default.
- NCIT_C1022 hasExactSynonym "(2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester)" @default.
- NCIT_C1022 hasExactSynonym "3-((3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl)carbonyl)benzoic acid, 6-(benzoyloxy)-3-cyano-2-pyridinyl ester" @default.
- NCIT_C1022 hasExactSynonym "3-[3-(6-Benzoyloxy-3-cyrano-2-pyridyloxycarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil" @default.
- NCIT_C1022 hasExactSynonym "BOF-A2" @default.
- NCIT_C1022 hasExactSynonym "EMITEFUR" @default.
- NCIT_C1022 hasExactSynonym "Emitefur" @default.
- NCIT_C1022 hasExactSynonym "Last-F" @default.
- NCIT_C1022 hasExactSynonym "[[Ethoxymethyl-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 6-(Benzoyloxy)-3-cyano-2-pyridinyl Ester" @default.
- NCIT_C1022 hasExactSynonym "emitefur" @default.
- NCIT_C1022 inSubset NCIT_C128784 @default.
- NCIT_C1022 inSubset NCIT_C157711 @default.
- NCIT_C1022 inSubset NCIT_C157712 @default.
- NCIT_C1022 inSubset NCIT_C177537 @default.
- NCIT_C1022 inSubset NCIT_C63923 @default.
- NCIT_C1022 type Class @default.
- NCIT_C1022 isDefinedBy ncit.owl @default.
- NCIT_C1022 label "Emitefur" @default.
- NCIT_C1022 subClassOf NCIT_C1022 @default.
- NCIT_C1022 subClassOf NCIT_C1557 @default.
- NCIT_C1022 subClassOf NCIT_C186664 @default.
- NCIT_C1022 subClassOf NCIT_C1908 @default.
- NCIT_C1022 subClassOf NCIT_C1909 @default.
- NCIT_C1022 subClassOf NCIT_C272 @default.
- NCIT_C1022 subClassOf NCIT_C274 @default.