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- NCIT_C102535 IAO_0000115 "A humanized monoclonal antibody (MoAb) directed against the human receptor tyrosine-protein kinase ErbB-3 (HER3) with potential antineoplastic activity. Anti-ErbB3 MoAb AV-203 binds to and inhibits both ligand neuregulin-1 (NRG-1)-dependent and ligand-independent ErbB3 activation, which may result in inhibition of ErbB3-dependent PI3K/Akt signaling and may lead to inhibition of cellular proliferation and differentiation. ErbB3, a member of the epidermal growth factor receptor (EGFR) family, is frequently overexpressed in solid tumors and its overexpression generally correlates with poor prognosis and tumor resistance; it has no active kinase domain itself but is activated through heterodimerization with other members of the EGFR receptor family that do." @default.
- NCIT_C102535 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102535 NCIT_A7 NCIT_C18490 @default.
- NCIT_C102535 NCIT_NHC0 "C102535" @default.
- NCIT_C102535 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102535 NCIT_P107 "Anti-ErbB3 Monoclonal Antibody AV-203" @default.
- NCIT_C102535 NCIT_P108 "Anti-ErbB3 Monoclonal Antibody AV-203" @default.
- NCIT_C102535 NCIT_P207 "C3640798" @default.
- NCIT_C102535 NCIT_P210 "1353581-77-7" @default.
- NCIT_C102535 NCIT_P319 "841P9W25WA" @default.
- NCIT_C102535 NCIT_P322 "CTRP" @default.
- NCIT_C102535 NCIT_P322 "FDA" @default.
- NCIT_C102535 NCIT_P322 "GDC" @default.
- NCIT_C102535 NCIT_P329 "734410" @default.
- NCIT_C102535 NCIT_P330 "734410" @default.
- NCIT_C102535 NCIT_P375 "Anti-ErbB3 Monoclonal Antibody AV-203" @default.
- NCIT_C102535 NCIT_P399 "734410" @default.
- NCIT_C102535 NCIT_R124 NCIT_C17710 @default.
- NCIT_C102535 NCIT_R124 NCIT_C17828 @default.
- NCIT_C102535 NCIT_R124 NCIT_C18219 @default.
- NCIT_C102535 NCIT_R124 NCIT_C19986 @default.
- NCIT_C102535 NCIT_R124 NCIT_C40474 @default.
- NCIT_C102535 normalizedInformationContent "100" @default.
- NCIT_C102535 referenceCount "1" @default.
- NCIT_C102535 hasExactSynonym "AV 203" @default.
- NCIT_C102535 hasExactSynonym "AV-203" @default.
- NCIT_C102535 hasExactSynonym "AV203" @default.
- NCIT_C102535 hasExactSynonym "Anti-ErbB3 MoAb AV-203" @default.
- NCIT_C102535 hasExactSynonym "Anti-ErbB3 Monoclonal Antibody AV-203" @default.
- NCIT_C102535 hasExactSynonym "CAN-017" @default.
- NCIT_C102535 inSubset NCIT_C116977 @default.
- NCIT_C102535 inSubset NCIT_C116978 @default.
- NCIT_C102535 inSubset NCIT_C128784 @default.
- NCIT_C102535 inSubset NCIT_C157711 @default.
- NCIT_C102535 inSubset NCIT_C157712 @default.
- NCIT_C102535 inSubset NCIT_C176424 @default.
- NCIT_C102535 inSubset NCIT_C177537 @default.
- NCIT_C102535 inSubset NCIT_C63923 @default.
- NCIT_C102535 type Class @default.
- NCIT_C102535 isDefinedBy ncit.owl @default.
- NCIT_C102535 label "Anti-ErbB3 Monoclonal Antibody AV-203" @default.
- NCIT_C102535 subClassOf NCIT_C102535 @default.
- NCIT_C102535 subClassOf NCIT_C129821 @default.
- NCIT_C102535 subClassOf NCIT_C129822 @default.
- NCIT_C102535 subClassOf NCIT_C163758 @default.
- NCIT_C102535 subClassOf NCIT_C1908 @default.
- NCIT_C102535 subClassOf NCIT_C1909 @default.
- NCIT_C102535 subClassOf NCIT_C199383 @default.
- NCIT_C102535 subClassOf NCIT_C199386 @default.
- NCIT_C102535 subClassOf NCIT_C20401 @default.
- NCIT_C102535 subClassOf NCIT_C274 @default.
- NCIT_C102535 subClassOf NCIT_C307 @default.
- NCIT_C102535 subClassOf NCIT_C308 @default.