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- NCIT_C102546 IAO_0000115 "An orally available, small molecule inhibitor of CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1), with potential antineoplastic activity. Selinexor modifies the essential CRM1-cargo binding residue cysteine-528, thereby irreversibly inactivates CRM1-mediated nuclear export of cargo proteins such as tumor suppressor proteins (TSPs), including p53, p21, BRCA1/2, pRB, FOXO, and other growth regulatory proteins. As a result, this agent, via the approach of selective inhibition of nuclear export (SINE), restores endogenous tumor suppressing processes to selectively eliminate tumor cells while sparing normal cells. CRM1, the major export factor for proteins from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types." @default.
- NCIT_C102546 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102546 NCIT_A7 NCIT_C99488 @default.
- NCIT_C102546 NCIT_NHC0 "C102546" @default.
- NCIT_C102546 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102546 NCIT_P107 "Selinexor" @default.
- NCIT_C102546 NCIT_P108 "Selinexor" @default.
- NCIT_C102546 NCIT_P207 "C3640806" @default.
- NCIT_C102546 NCIT_P210 "1393477-72-9" @default.
- NCIT_C102546 NCIT_P302 "multiple myeloma" @default.
- NCIT_C102546 NCIT_P319 "31TZ62FO8F" @default.
- NCIT_C102546 NCIT_P322 "CTRP" @default.
- NCIT_C102546 NCIT_P322 "FDA" @default.
- NCIT_C102546 NCIT_P322 "GDC" @default.
- NCIT_C102546 NCIT_P329 "734824" @default.
- NCIT_C102546 NCIT_P330 "734824" @default.
- NCIT_C102546 NCIT_P375 "Selinexor" @default.
- NCIT_C102546 NCIT_P399 "734824" @default.
- NCIT_C102546 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C102546 referenceCount "7" @default.
- NCIT_C102546 hasExactSynonym "2-Propenoic Acid, 3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-Pyrazinyl)hydrazide, (2Z)-" @default.
- NCIT_C102546 hasExactSynonym "ATG-010" @default.
- NCIT_C102546 hasExactSynonym "CRM1 Nuclear Export Inhibitor KPT-330" @default.
- NCIT_C102546 hasExactSynonym "KPT-330" @default.
- NCIT_C102546 hasExactSynonym "Nexpovio" @default.
- NCIT_C102546 hasExactSynonym "SELINEXOR" @default.
- NCIT_C102546 hasExactSynonym "SINE KPT-330" @default.
- NCIT_C102546 hasExactSynonym "Selective Inhibitor of Nuclear Export KPT-330" @default.
- NCIT_C102546 hasExactSynonym "Selinexor" @default.
- NCIT_C102546 hasExactSynonym "Xpovio" @default.
- NCIT_C102546 inSubset NCIT_C116977 @default.
- NCIT_C102546 inSubset NCIT_C116978 @default.
- NCIT_C102546 inSubset NCIT_C128784 @default.
- NCIT_C102546 inSubset NCIT_C157711 @default.
- NCIT_C102546 inSubset NCIT_C157712 @default.
- NCIT_C102546 inSubset NCIT_C173381 @default.
- NCIT_C102546 inSubset NCIT_C173383 @default.
- NCIT_C102546 inSubset NCIT_C176424 @default.
- NCIT_C102546 inSubset NCIT_C177537 @default.
- NCIT_C102546 inSubset NCIT_C63923 @default.
- NCIT_C102546 type Class @default.
- NCIT_C102546 isDefinedBy ncit.owl @default.
- NCIT_C102546 label "Selinexor" @default.
- NCIT_C102546 subClassOf NCIT_C102546 @default.
- NCIT_C102546 subClassOf NCIT_C129824 @default.
- NCIT_C102546 subClassOf NCIT_C1908 @default.
- NCIT_C102546 subClassOf NCIT_C1909 @default.
- NCIT_C102546 subClassOf NCIT_C198515 @default.
- NCIT_C102546 subClassOf NCIT_C2189 @default.
- NCIT_C102546 subClassOf NCIT_C274 @default.