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- NCIT_C102564 IAO_0000115 "A novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. Capivasertib binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers." @default.
- NCIT_C102564 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102564 NCIT_A7 NCIT_C41625 @default.
- NCIT_C102564 NCIT_NHC0 "C102564" @default.
- NCIT_C102564 NCIT_P106 "Organic Chemical" @default.
- NCIT_C102564 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102564 NCIT_P107 "Capivasertib" @default.
- NCIT_C102564 NCIT_P108 "Capivasertib" @default.
- NCIT_C102564 NCIT_P207 "C3502775" @default.
- NCIT_C102564 NCIT_P210 "1143532-39-1" @default.
- NCIT_C102564 NCIT_P319 "WFR23M21IE" @default.
- NCIT_C102564 NCIT_P322 "CTRP" @default.
- NCIT_C102564 NCIT_P322 "FDA" @default.
- NCIT_C102564 NCIT_P322 "GDC" @default.
- NCIT_C102564 NCIT_P329 "688304" @default.
- NCIT_C102564 NCIT_P330 "688304" @default.
- NCIT_C102564 NCIT_P375 "Capivasertib" @default.
- NCIT_C102564 NCIT_P399 "688304" @default.
- NCIT_C102564 normalizedInformationContent "100" @default.
- NCIT_C102564 referenceCount "1" @default.
- NCIT_C102564 hasExactSynonym "AZD5363" @default.
- NCIT_C102564 hasExactSynonym "CAPIVASERTIB" @default.
- NCIT_C102564 hasExactSynonym "Capivasertib" @default.
- NCIT_C102564 inSubset NCIT_C116977 @default.
- NCIT_C102564 inSubset NCIT_C116978 @default.
- NCIT_C102564 inSubset NCIT_C128784 @default.
- NCIT_C102564 inSubset NCIT_C157711 @default.
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- NCIT_C102564 inSubset NCIT_C176424 @default.
- NCIT_C102564 inSubset NCIT_C177537 @default.
- NCIT_C102564 inSubset NCIT_C63923 @default.
- NCIT_C102564 type Class @default.
- NCIT_C102564 isDefinedBy ncit.owl @default.
- NCIT_C102564 label "Capivasertib" @default.
- NCIT_C102564 subClassOf NCIT_C102564 @default.
- NCIT_C102564 subClassOf NCIT_C129824 @default.
- NCIT_C102564 subClassOf NCIT_C129825 @default.
- NCIT_C102564 subClassOf NCIT_C1404 @default.
- NCIT_C102564 subClassOf NCIT_C155764 @default.
- NCIT_C102564 subClassOf NCIT_C1742 @default.
- NCIT_C102564 subClassOf NCIT_C1908 @default.
- NCIT_C102564 subClassOf NCIT_C1909 @default.
- NCIT_C102564 subClassOf NCIT_C2189 @default.
- NCIT_C102564 subClassOf NCIT_C274 @default.
- NCIT_C102564 subClassOf NCIT_C471 @default.
- NCIT_C102564 subClassOf NCIT_C61074 @default.