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- NCIT_C102566 IAO_0000115 "An immunoconjugate consisting of the humanized monoclonal antibody M9346A against folate receptor 1 (FOLR1) conjugated, via the disulfide-containing cleavable linker sulfo-SPDB, to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. The anti-FOLR1 monoclonal antibody moiety of mirvetuximab soravtansine targets and binds to the cell surface antigen FOLR1. After antibody-antigen interaction and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, thereby inhibiting cell division and cell growth of FOLR1-expressing tumor cells. FOLR1, a member of the folate receptor family is overexpressed on a variety of epithelial-derived cancer cells. The sulfo-SPDB linker prevents cleavage in the bloodstream and may improve this agent's efficacy in multidrug resistant tumor cells." @default.
- NCIT_C102566 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102566 NCIT_A7 NCIT_C39284 @default.
- NCIT_C102566 NCIT_NHC0 "C102566" @default.
- NCIT_C102566 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102566 NCIT_P107 "Mirvetuximab Soravtansine" @default.
- NCIT_C102566 NCIT_P108 "Mirvetuximab Soravtansine" @default.
- NCIT_C102566 NCIT_P207 "C3640818" @default.
- NCIT_C102566 NCIT_P210 "1453084-37-1" @default.
- NCIT_C102566 NCIT_P302 "adult patients with folate receptor alpha (FRα) positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer." @default.
- NCIT_C102566 NCIT_P319 "98DE7VN88D" @default.
- NCIT_C102566 NCIT_P322 "CTRP" @default.
- NCIT_C102566 NCIT_P322 "FDA" @default.
- NCIT_C102566 NCIT_P322 "GDC" @default.
- NCIT_C102566 NCIT_P329 "734941" @default.
- NCIT_C102566 NCIT_P330 "734941" @default.
- NCIT_C102566 NCIT_P375 "Mirvetuximab Soravtansine" @default.
- NCIT_C102566 NCIT_P399 "734941" @default.
- NCIT_C102566 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C102566 referenceCount "2" @default.
- NCIT_C102566 hasExactSynonym "Elahere" @default.
- NCIT_C102566 hasExactSynonym "IMGN853" @default.
- NCIT_C102566 hasExactSynonym "M9346A-sulfo-SPDB-DM4" @default.
- NCIT_C102566 hasExactSynonym "MIRVETUXIMAB SORAVTANSINE" @default.
- NCIT_C102566 hasExactSynonym "Mirvetuximab Soravtansine" @default.
- NCIT_C102566 hasExactSynonym "mirvetuximab Soravtansine-gynx" @default.
- NCIT_C102566 inSubset NCIT_C116977 @default.
- NCIT_C102566 inSubset NCIT_C116978 @default.
- NCIT_C102566 inSubset NCIT_C128784 @default.
- NCIT_C102566 inSubset NCIT_C157711 @default.
- NCIT_C102566 inSubset NCIT_C157712 @default.
- NCIT_C102566 inSubset NCIT_C176424 @default.
- NCIT_C102566 inSubset NCIT_C177537 @default.
- NCIT_C102566 inSubset NCIT_C63923 @default.
- NCIT_C102566 type Class @default.
- NCIT_C102566 isDefinedBy ncit.owl @default.
- NCIT_C102566 label "Mirvetuximab Soravtansine" @default.
- NCIT_C102566 subClassOf NCIT_C102566 @default.
- NCIT_C102566 subClassOf NCIT_C129821 @default.
- NCIT_C102566 subClassOf NCIT_C129823 @default.
- NCIT_C102566 subClassOf NCIT_C1512 @default.
- NCIT_C102566 subClassOf NCIT_C163758 @default.
- NCIT_C102566 subClassOf NCIT_C1908 @default.
- NCIT_C102566 subClassOf NCIT_C1909 @default.
- NCIT_C102566 subClassOf NCIT_C200086 @default.
- NCIT_C102566 subClassOf NCIT_C200114 @default.
- NCIT_C102566 subClassOf NCIT_C274 @default.
- NCIT_C102566 subClassOf NCIT_C307 @default.
- NCIT_C102566 subClassOf NCIT_C308 @default.