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- NCIT_C102568 IAO_0000115 "A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile." @default.
- NCIT_C102568 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102568 NCIT_NHC0 "C102568" @default.
- NCIT_C102568 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102568 NCIT_P108 "Docetaxel Lipid Microspheres" @default.
- NCIT_C102568 NCIT_P208 "CL436875" @default.
- NCIT_C102568 NCIT_P322 "GDC" @default.
- NCIT_C102568 NCIT_P329 "735255" @default.
- NCIT_C102568 NCIT_P330 "735255" @default.
- NCIT_C102568 NCIT_P375 "Docetaxel Lipid Microspheres" @default.
- NCIT_C102568 NCIT_P399 "735255" @default.
- NCIT_C102568 NCIT_R124 NCIT_C17828 @default.
- NCIT_C102568 NCIT_R124 NCIT_C20480 @default.
- NCIT_C102568 NCIT_R124 NCIT_C40795 @default.
- NCIT_C102568 NCIT_R124 NCIT_C40798 @default.
- NCIT_C102568 normalizedInformationContent "100" @default.
- NCIT_C102568 referenceCount "1" @default.
- NCIT_C102568 hasExactSynonym "DLE" @default.
- NCIT_C102568 hasExactSynonym "DT-LM" @default.
- NCIT_C102568 hasExactSynonym "Docetaxel Lipid Emulsion" @default.
- NCIT_C102568 hasExactSynonym "Docetaxel Lipid Microspheres" @default.
- NCIT_C102568 inSubset NCIT_C128784 @default.
- NCIT_C102568 inSubset NCIT_C157711 @default.
- NCIT_C102568 inSubset NCIT_C157712 @default.
- NCIT_C102568 inSubset NCIT_C176424 @default.
- NCIT_C102568 inSubset NCIT_C177537 @default.
- NCIT_C102568 type Class @default.
- NCIT_C102568 isDefinedBy ncit.owl @default.
- NCIT_C102568 label "Docetaxel Lipid Microspheres" @default.
- NCIT_C102568 subClassOf NCIT_C102568 @default.
- NCIT_C102568 subClassOf NCIT_C186664 @default.
- NCIT_C102568 subClassOf NCIT_C1908 @default.
- NCIT_C102568 subClassOf NCIT_C1909 @default.
- NCIT_C102568 subClassOf NCIT_C25974 @default.
- NCIT_C102568 subClassOf NCIT_C273 @default.
- NCIT_C102568 subClassOf NCIT_C274 @default.
- NCIT_C102568 subClassOf NCIT_C67437 @default.