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- NCIT_C102847 IAO_0000115 "A sustained release (SR) implant wafer containing the lipophilic nitrosourea carmustine (BCNU) with antineoplastic activity. Upon intracranial administration of the implant wafer and subsequent release of BCNU from the wafer, this agent alkylates and cross-links DNA during all phases of the cell cycle, resulting in the disruption of DNA function, cell cycle arrest, and apoptosis. This wafer contains the biodegradable copolymer PLGA (poly(lactide-co-glycolide) as the major drug delivery vehicle which is slowly degraded into water and carbon dioxide thereby continously releasing BCNU over approximately 3-4 weeks. Compared to systemic administration of BCNU alone, this local SR formulation is able to maintain higher drug concentrations locally over a longer period of time while minimizing exposure to other tissues." @default.
- NCIT_C102847 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102847 NCIT_NHC0 "C102847" @default.
- NCIT_C102847 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102847 NCIT_P108 "Carmustine Sustained-Release Implant Wafer" @default.
- NCIT_C102847 NCIT_P208 "CL437131" @default.
- NCIT_C102847 NCIT_P322 "GDC" @default.
- NCIT_C102847 NCIT_P329 "737196" @default.
- NCIT_C102847 NCIT_P330 "737196" @default.
- NCIT_C102847 NCIT_P375 "Carmustine Sustained-Release Implant Wafer" @default.
- NCIT_C102847 NCIT_P399 "737196" @default.
- NCIT_C102847 normalizedInformationContent "100" @default.
- NCIT_C102847 referenceCount "1" @default.
- NCIT_C102847 hasExactSynonym "CASANT Wafer" @default.
- NCIT_C102847 hasExactSynonym "Carmustine Sustained-Release Implant Wafer" @default.
- NCIT_C102847 inSubset NCIT_C128784 @default.
- NCIT_C102847 inSubset NCIT_C157711 @default.
- NCIT_C102847 inSubset NCIT_C157712 @default.
- NCIT_C102847 inSubset NCIT_C176424 @default.
- NCIT_C102847 inSubset NCIT_C177537 @default.
- NCIT_C102847 type Class @default.
- NCIT_C102847 isDefinedBy ncit.owl @default.
- NCIT_C102847 label "Carmustine Sustained-Release Implant Wafer" @default.
- NCIT_C102847 subClassOf NCIT_C102847 @default.
- NCIT_C102847 subClassOf NCIT_C186664 @default.
- NCIT_C102847 subClassOf NCIT_C1908 @default.
- NCIT_C102847 subClassOf NCIT_C1909 @default.
- NCIT_C102847 subClassOf NCIT_C2163 @default.
- NCIT_C102847 subClassOf NCIT_C274 @default.
- NCIT_C102847 subClassOf NCIT_C2842 @default.