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- NCIT_C102849 IAO_0000115 "A synthetic peptide targeting the substrates of casein kinase 2 (CK2), with potential antineoplastic activity. Upon administration and nucleolar localization, CK2-targeting synthetic peptide CIGB-300 binds to phosphoacceptor sites on the CK2 substrates, in particular the oncoprotein nucleophosmin (B23 or NPM1). This blocks the activation of B23 and induces apoptosis, thereby inhibiting tumor cell growth in susceptible tumor cells. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. Overexpression of B23 has been correlated with increased cellular growth and proliferation as well as inhibition of differentiation and apoptosis." @default.
- NCIT_C102849 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102849 NCIT_NHC0 "C102849" @default.
- NCIT_C102849 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102849 NCIT_P108 "CK2-targeting Synthetic Peptide CIGB-300" @default.
- NCIT_C102849 NCIT_P207 "C2605865" @default.
- NCIT_C102849 NCIT_P210 "1072877-99-6" @default.
- NCIT_C102849 NCIT_P319 "X6HMT2EDH9" @default.
- NCIT_C102849 NCIT_P322 "FDA" @default.
- NCIT_C102849 NCIT_P322 "GDC" @default.
- NCIT_C102849 NCIT_P329 "737263" @default.
- NCIT_C102849 NCIT_P330 "737263" @default.
- NCIT_C102849 NCIT_P375 "CK2-targeting Synthetic Peptide CIGB-300" @default.
- NCIT_C102849 NCIT_P399 "737263" @default.
- NCIT_C102849 normalizedInformationContent "100" @default.
- NCIT_C102849 referenceCount "1" @default.
- NCIT_C102849 hasExactSynonym "CIBG-300" @default.
- NCIT_C102849 hasExactSynonym "CIGB-300" @default.
- NCIT_C102849 hasExactSynonym "CIGB-325" @default.
- NCIT_C102849 hasExactSynonym "CK2-targeting Synthetic Peptide CIGB-300" @default.
- NCIT_C102849 hasExactSynonym "P15-tat" @default.
- NCIT_C102849 inSubset NCIT_C128784 @default.
- NCIT_C102849 inSubset NCIT_C157711 @default.
- NCIT_C102849 inSubset NCIT_C157712 @default.
- NCIT_C102849 inSubset NCIT_C173381 @default.
- NCIT_C102849 inSubset NCIT_C173383 @default.
- NCIT_C102849 inSubset NCIT_C176424 @default.
- NCIT_C102849 inSubset NCIT_C177537 @default.
- NCIT_C102849 inSubset NCIT_C63923 @default.
- NCIT_C102849 type Class @default.
- NCIT_C102849 isDefinedBy ncit.owl @default.
- NCIT_C102849 label "CK2-targeting Synthetic Peptide CIGB-300" @default.
- NCIT_C102849 subClassOf NCIT_C102849 @default.
- NCIT_C102849 subClassOf NCIT_C129824 @default.
- NCIT_C102849 subClassOf NCIT_C1908 @default.
- NCIT_C102849 subClassOf NCIT_C1909 @default.
- NCIT_C102849 subClassOf NCIT_C2189 @default.
- NCIT_C102849 subClassOf NCIT_C274 @default.