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- NCIT_C102851 IAO_0000115 "A multivalent Kunitz-type serine protease inhibitor derived from human urine, with potential protective, anti-fibrinolytic and anticoagulant activities. Upon administration, ulinastatin (or urinary trypsinogen inhibitor) inhibits the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. In addition, ulinastatin inhibits the excessive release of proinflammatory mediators, such as tumor necrosis factor-alpha, interleukin-6 and -8, and chemokines. Altogether, this agent may improve the microcirculation, perfusion and function of tissues and may protect organ injury." @default.
- NCIT_C102851 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102851 NCIT_NHC0 "C102851" @default.
- NCIT_C102851 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102851 NCIT_P108 "Ulinastatin" @default.
- NCIT_C102851 NCIT_P207 "C0077906" @default.
- NCIT_C102851 NCIT_P210 "80449-32-7" @default.
- NCIT_C102851 NCIT_P319 "OR3S9IF86U" @default.
- NCIT_C102851 NCIT_P322 "FDA" @default.
- NCIT_C102851 NCIT_P322 "GDC" @default.
- NCIT_C102851 NCIT_P329 "737612" @default.
- NCIT_C102851 NCIT_P330 "737612" @default.
- NCIT_C102851 NCIT_P375 "Ulinastatin" @default.
- NCIT_C102851 NCIT_P399 "737612" @default.
- NCIT_C102851 normalizedInformationContent "100" @default.
- NCIT_C102851 referenceCount "1" @default.
- NCIT_C102851 hasExactSynonym "Bikunin" @default.
- NCIT_C102851 hasExactSynonym "Trypsin Inhibitor, Bikunin" @default.
- NCIT_C102851 hasExactSynonym "ULINASTATIN" @default.
- NCIT_C102851 hasExactSynonym "UTI" @default.
- NCIT_C102851 hasExactSynonym "Ulinastatin" @default.
- NCIT_C102851 hasExactSynonym "Urinary Trypsin Inhibitor" @default.
- NCIT_C102851 inSubset NCIT_C128784 @default.
- NCIT_C102851 inSubset NCIT_C157711 @default.
- NCIT_C102851 inSubset NCIT_C157712 @default.
- NCIT_C102851 inSubset NCIT_C173381 @default.
- NCIT_C102851 inSubset NCIT_C173383 @default.
- NCIT_C102851 inSubset NCIT_C176424 @default.
- NCIT_C102851 inSubset NCIT_C177537 @default.
- NCIT_C102851 inSubset NCIT_C63923 @default.
- NCIT_C102851 type Class @default.
- NCIT_C102851 isDefinedBy ncit.owl @default.
- NCIT_C102851 label "Ulinastatin" @default.
- NCIT_C102851 subClassOf NCIT_C102851 @default.
- NCIT_C102851 subClassOf NCIT_C1908 @default.
- NCIT_C102851 subClassOf NCIT_C1909 @default.
- NCIT_C102851 subClassOf NCIT_C471 @default.
- NCIT_C102851 subClassOf NCIT_C783 @default.