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- NCIT_C102854 IAO_0000115 "A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Efbemalenograstim alfa binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy." @default.
- NCIT_C102854 NCIT_NHC0 "C102854" @default.
- NCIT_C102854 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C102854 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102854 NCIT_P107 "Efbemalenograstim alfa" @default.
- NCIT_C102854 NCIT_P108 "Efbemalenograstim alfa" @default.
- NCIT_C102854 NCIT_P208 "CL437135" @default.
- NCIT_C102854 NCIT_P210 "2200269-79-8" @default.
- NCIT_C102854 NCIT_P319 "5UPW5HJW3O" @default.
- NCIT_C102854 NCIT_P322 "CTRP" @default.
- NCIT_C102854 NCIT_P322 "FDA" @default.
- NCIT_C102854 NCIT_P329 "737722" @default.
- NCIT_C102854 NCIT_P330 "737722" @default.
- NCIT_C102854 NCIT_P399 "737722" @default.
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- NCIT_C102854 NCIT_R146 NCIT_C38991 @default.
- NCIT_C102854 NCIT_R72 NCIT_C12219 @default.
- NCIT_C102854 NCIT_R72 NCIT_C12508 @default.
- NCIT_C102854 NCIT_R72 NCIT_C12551 @default.
- NCIT_C102854 NCIT_R72 NCIT_C12662 @default.
- NCIT_C102854 NCIT_R72 NCIT_C21599 @default.
- NCIT_C102854 NCIT_R72 NCIT_C32725 @default.
- NCIT_C102854 normalizedInformationContent "100" @default.
- NCIT_C102854 referenceCount "1" @default.
- NCIT_C102854 hasExactSynonym "EFBEMALENOGRASTIM ALFA" @default.
- NCIT_C102854 hasExactSynonym "Efbemalenograstim alfa" @default.
- NCIT_C102854 hasExactSynonym "F-627" @default.
- NCIT_C102854 hasExactSynonym "F627" @default.
- NCIT_C102854 hasExactSynonym "Recombinant Dimeric G-CSF Fusion Protein F627" @default.
- NCIT_C102854 hasExactSynonym "Rh G-CSF Fc Fusion Protein F-627" @default.
- NCIT_C102854 inSubset NCIT_C116977 @default.
- NCIT_C102854 inSubset NCIT_C116978 @default.
- NCIT_C102854 inSubset NCIT_C176424 @default.
- NCIT_C102854 inSubset NCIT_C63923 @default.
- NCIT_C102854 type Class @default.
- NCIT_C102854 isDefinedBy ncit.owl @default.
- NCIT_C102854 label "Efbemalenograstim alfa" @default.
- NCIT_C102854 subClassOf NCIT_C102854 @default.
- NCIT_C102854 subClassOf NCIT_C1283 @default.
- NCIT_C102854 subClassOf NCIT_C1287 @default.
- NCIT_C102854 subClassOf NCIT_C1908 @default.
- NCIT_C102854 subClassOf NCIT_C1909 @default.
- NCIT_C102854 subClassOf NCIT_C2395 @default.
- NCIT_C102854 subClassOf NCIT_C307 @default.
- NCIT_C102854 subClassOf NCIT_C308 @default.
- NCIT_C102854 subClassOf NCIT_C387 @default.
- NCIT_C102854 subClassOf NCIT_C530 @default.