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- NCIT_C102880 IAO_0000115 "Tablets for oral suspension containing everolimus, a derivative of the natural macrocyclic lactone sirolimus, with immunosuppressive and antineoplastic activities. After suspension of the everolimus tablets in water and oral administration, this agent inhibits the activation of the serine/threonine kinase mammalian target of rapamycin (mTOR) by binding to mTOR's cytosolic receptor immunophilin FK Binding Protein-12 (FKBP-12). Inhibition of the mTOR complex may result in the inhibition of the phosphatidylinositol 3 kinase/Akt/mTOR pathway and an inhibition in the expression of vascular endothelial cell growth factor (VEGF) and hypoxia-inducible factor. Ultimately, this may result in decreased tumor cell proliferation and tumor angiogenesis. This pediatric formulation can dissolve easily in a small volume of water making it easier to swallow and is available in smaller dose increments thereby allowing for greater dosing flexibility." @default.
- NCIT_C102880 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102880 NCIT_NHC0 "C102880" @default.
- NCIT_C102880 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102880 NCIT_P108 "Everolimus Tablets for Oral Suspension" @default.
- NCIT_C102880 NCIT_P208 "CL437183" @default.
- NCIT_C102880 NCIT_P302 "tuberous sclerosis complex (TSC)-associated partial-onset seizures; TSC-associated subependymal giant cell astrocytoma (SEGA) and TSC-associated renal angiomyolipoma" @default.
- NCIT_C102880 NCIT_P322 "GDC" @default.
- NCIT_C102880 NCIT_P329 "739586" @default.
- NCIT_C102880 NCIT_P330 "739586" @default.
- NCIT_C102880 NCIT_P375 "Everolimus Tablets for Oral Suspension" @default.
- NCIT_C102880 NCIT_P399 "739586" @default.
- NCIT_C102880 normalizedInformationContent "100" @default.
- NCIT_C102880 referenceCount "1" @default.
- NCIT_C102880 hasExactSynonym "Afinitor Disperz" @default.
- NCIT_C102880 hasExactSynonym "Everolimus Tablets for Oral Suspension" @default.
- NCIT_C102880 inSubset NCIT_C128784 @default.
- NCIT_C102880 inSubset NCIT_C157711 @default.
- NCIT_C102880 inSubset NCIT_C157712 @default.
- NCIT_C102880 inSubset NCIT_C176424 @default.
- NCIT_C102880 inSubset NCIT_C177537 @default.
- NCIT_C102880 type Class @default.
- NCIT_C102880 isDefinedBy ncit.owl @default.
- NCIT_C102880 label "Everolimus Tablets for Oral Suspension" @default.
- NCIT_C102880 subClassOf NCIT_C102880 @default.
- NCIT_C102880 subClassOf NCIT_C129824 @default.
- NCIT_C102880 subClassOf NCIT_C129825 @default.
- NCIT_C102880 subClassOf NCIT_C1404 @default.
- NCIT_C102880 subClassOf NCIT_C163758 @default.
- NCIT_C102880 subClassOf NCIT_C1742 @default.
- NCIT_C102880 subClassOf NCIT_C1908 @default.
- NCIT_C102880 subClassOf NCIT_C1909 @default.
- NCIT_C102880 subClassOf NCIT_C2189 @default.
- NCIT_C102880 subClassOf NCIT_C2201 @default.
- NCIT_C102880 subClassOf NCIT_C274 @default.
- NCIT_C102880 subClassOf NCIT_C471 @default.
- NCIT_C102880 subClassOf NCIT_C61074 @default.