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- NCIT_C1029 IAO_0000115 "A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04)" @default.
- NCIT_C1029 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1029 NCIT_NHC0 "C1029" @default.
- NCIT_C1029 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1029 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1029 NCIT_P107 "Buthionine Sulfoximine" @default.
- NCIT_C1029 NCIT_P108 "Buthionine Sulfoximine" @default.
- NCIT_C1029 NCIT_P175 "326231" @default.
- NCIT_C1029 NCIT_P207 "C0054252" @default.
- NCIT_C1029 NCIT_P210 "83730-53-4" @default.
- NCIT_C1029 NCIT_P319 "EEY8DZS103" @default.
- NCIT_C1029 NCIT_P322 "CTRP" @default.
- NCIT_C1029 NCIT_P322 "FDA" @default.
- NCIT_C1029 NCIT_P322 "GDC" @default.
- NCIT_C1029 NCIT_P325 "A drug that may help prevent resistance to some anticancer drugs." @default.
- NCIT_C1029 NCIT_P329 "39123" @default.
- NCIT_C1029 NCIT_P330 "39123" @default.
- NCIT_C1029 NCIT_P350 "C8H18N2O3S" @default.
- NCIT_C1029 NCIT_P366 "Buthionine_Sulfoximine" @default.
- NCIT_C1029 NCIT_P375 "Buthionine Sulfoximine" @default.
- NCIT_C1029 NCIT_P399 "39123" @default.
- NCIT_C1029 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1029 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1029 NCIT_R124 NCIT_C28498 @default.
- NCIT_C1029 NCIT_R124 NCIT_C40576 @default.
- NCIT_C1029 NCIT_R124 NCIT_C40577 @default.
- NCIT_C1029 NCIT_R125 NCIT_C16956 @default.
- NCIT_C1029 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1029 NCIT_R125 NCIT_C20150 @default.
- NCIT_C1029 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1029 NCIT_R125 NCIT_C21065 @default.
- NCIT_C1029 NCIT_R125 NCIT_C40715 @default.
- NCIT_C1029 NCIT_R125 NCIT_C40765 @default.
- NCIT_C1029 NCIT_R125 NCIT_C41515 @default.
- NCIT_C1029 NCIT_R125 NCIT_C51037 @default.
- NCIT_C1029 NCIT_R146 NCIT_C16602 @default.
- NCIT_C1029 NCIT_R146 NCIT_C21176 @default.
- NCIT_C1029 NCIT_R146 NCIT_C26548 @default.
- NCIT_C1029 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1029 referenceCount "2" @default.
- NCIT_C1029 hasExactSynonym "2-Amino-4-(S-butylsulfonimidoyl) Butanoic Acid" @default.
- NCIT_C1029 hasExactSynonym "BSO" @default.
- NCIT_C1029 hasExactSynonym "BUTHIONINE SULFOXIMINE, L-" @default.
- NCIT_C1029 hasExactSynonym "Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-" @default.
- NCIT_C1029 hasExactSynonym "Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-" @default.
- NCIT_C1029 hasExactSynonym "Buthionine Sulfoximine" @default.
- NCIT_C1029 hasExactSynonym "Buthionine Sulphoximine" @default.
- NCIT_C1029 hasExactSynonym "L-Buthionine Sulfoximine" @default.
- NCIT_C1029 hasExactSynonym "L-Buthionine sulfoximine" @default.
- NCIT_C1029 hasExactSynonym "S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine" @default.
- NCIT_C1029 hasExactSynonym "S-(n-Butyl)homocysteine Sulfoximine" @default.
- NCIT_C1029 hasExactSynonym "buthionine sulfoximine" @default.
- NCIT_C1029 inSubset NCIT_C116977 @default.
- NCIT_C1029 inSubset NCIT_C116978 @default.
- NCIT_C1029 inSubset NCIT_C128784 @default.
- NCIT_C1029 inSubset NCIT_C157711 @default.
- NCIT_C1029 inSubset NCIT_C157712 @default.
- NCIT_C1029 inSubset NCIT_C176424 @default.
- NCIT_C1029 inSubset NCIT_C177537 @default.
- NCIT_C1029 inSubset NCIT_C63923 @default.
- NCIT_C1029 type Class @default.
- NCIT_C1029 isDefinedBy ncit.owl @default.
- NCIT_C1029 label "Buthionine Sulfoximine" @default.
- NCIT_C1029 subClassOf NCIT_C1029 @default.
- NCIT_C1029 subClassOf NCIT_C1908 @default.
- NCIT_C1029 subClassOf NCIT_C1909 @default.
- NCIT_C1029 subClassOf NCIT_C2130 @default.
- NCIT_C1029 subClassOf NCIT_C471 @default.
- NCIT_C1029 equivalentClass B5e6ca6e2b48b55ccee64ff1189311089 @default.
- NCIT_C1029 equivalentClass Bca9785b1fba96219e73e8fce73fb7953 @default.