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- NCIT_C102980 IAO_0000115 "An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody (AGS-16C) directed to the ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3), conjugated via a non-cleavable linker to monomethyl auristatin F (MMAF), an auristatin derivative and a potent microtubule inhibitor, that has potential antineoplastic activity. Upon intravenous administration of ADC AGS-16C3F, the monoclonal antibody moiety of this conjugate selectively binds to ENPP3 then is internalized and undergoes proteolytic cleavage to release MMAF. MMAF binds to and inhibits tubulin polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. While normally expressed at low levels in the proximal tubules of the kidney, the type II transmembrane glycoprotein ENPP3 has been found to be overexpressed in renal neoplasms." @default.
- NCIT_C102980 NCIT_A32 NCIT_C1909 @default.
- NCIT_C102980 NCIT_A7 NCIT_C147048 @default.
- NCIT_C102980 NCIT_NHC0 "C102980" @default.
- NCIT_C102980 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102980 NCIT_P107 "Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F" @default.
- NCIT_C102980 NCIT_P108 "Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F" @default.
- NCIT_C102980 NCIT_P208 "CL437217" @default.
- NCIT_C102980 NCIT_P319 "VC1D38AGN9" @default.
- NCIT_C102980 NCIT_P322 "CTRP" @default.
- NCIT_C102980 NCIT_P322 "FDA" @default.
- NCIT_C102980 NCIT_P322 "GDC" @default.
- NCIT_C102980 NCIT_P329 "739766" @default.
- NCIT_C102980 NCIT_P330 "739766" @default.
- NCIT_C102980 NCIT_P375 "Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F" @default.
- NCIT_C102980 NCIT_P399 "739766" @default.
- NCIT_C102980 normalizedInformationContent "100" @default.
- NCIT_C102980 referenceCount "1" @default.
- NCIT_C102980 hasExactSynonym "ADC AGS-16C3F" @default.
- NCIT_C102980 hasExactSynonym "AGS-16C3F" @default.
- NCIT_C102980 hasExactSynonym "Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F" @default.
- NCIT_C102980 inSubset NCIT_C116977 @default.
- NCIT_C102980 inSubset NCIT_C116978 @default.
- NCIT_C102980 inSubset NCIT_C128784 @default.
- NCIT_C102980 inSubset NCIT_C157711 @default.
- NCIT_C102980 inSubset NCIT_C157712 @default.
- NCIT_C102980 inSubset NCIT_C176424 @default.
- NCIT_C102980 inSubset NCIT_C177537 @default.
- NCIT_C102980 inSubset NCIT_C63923 @default.
- NCIT_C102980 type Class @default.
- NCIT_C102980 isDefinedBy ncit.owl @default.
- NCIT_C102980 label "Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F" @default.
- NCIT_C102980 subClassOf NCIT_C102980 @default.
- NCIT_C102980 subClassOf NCIT_C129821 @default.
- NCIT_C102980 subClassOf NCIT_C129823 @default.
- NCIT_C102980 subClassOf NCIT_C1512 @default.
- NCIT_C102980 subClassOf NCIT_C1908 @default.
- NCIT_C102980 subClassOf NCIT_C1909 @default.
- NCIT_C102980 subClassOf NCIT_C274 @default.
- NCIT_C102980 subClassOf NCIT_C307 @default.
- NCIT_C102980 subClassOf NCIT_C308 @default.