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- NCIT_C103826 IAO_0000115 "An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Taladegib inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers." @default.
- NCIT_C103826 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103826 NCIT_A7 NCIT_C29980 @default.
- NCIT_C103826 NCIT_NHC0 "C103826" @default.
- NCIT_C103826 NCIT_P106 "Organic Chemical" @default.
- NCIT_C103826 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103826 NCIT_P107 "Taladegib" @default.
- NCIT_C103826 NCIT_P108 "Taladegib" @default.
- NCIT_C103826 NCIT_P207 "C3641628" @default.
- NCIT_C103826 NCIT_P210 "1258861-20-9" @default.
- NCIT_C103826 NCIT_P319 "QY8BWX1LJ5" @default.
- NCIT_C103826 NCIT_P322 "CTRP" @default.
- NCIT_C103826 NCIT_P322 "FDA" @default.
- NCIT_C103826 NCIT_P322 "GDC" @default.
- NCIT_C103826 NCIT_P329 "688313" @default.
- NCIT_C103826 NCIT_P330 "688313" @default.
- NCIT_C103826 NCIT_P375 "Taladegib" @default.
- NCIT_C103826 NCIT_P399 "688313" @default.
- NCIT_C103826 normalizedInformationContent "100" @default.
- NCIT_C103826 referenceCount "1" @default.
- NCIT_C103826 hasExactSynonym "4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide" @default.
- NCIT_C103826 hasExactSynonym "Benzamide, 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl)-4-piperidinyl)-2-(trifluoromethyl)-" @default.
- NCIT_C103826 hasExactSynonym "LY-2940680" @default.
- NCIT_C103826 hasExactSynonym "LY2940680" @default.
- NCIT_C103826 hasExactSynonym "TALADEGIB" @default.
- NCIT_C103826 hasExactSynonym "Taladegib" @default.
- NCIT_C103826 inSubset NCIT_C116977 @default.
- NCIT_C103826 inSubset NCIT_C116978 @default.
- NCIT_C103826 inSubset NCIT_C128784 @default.
- NCIT_C103826 inSubset NCIT_C157711 @default.
- NCIT_C103826 inSubset NCIT_C157712 @default.
- NCIT_C103826 inSubset NCIT_C176424 @default.
- NCIT_C103826 inSubset NCIT_C177537 @default.
- NCIT_C103826 inSubset NCIT_C63923 @default.
- NCIT_C103826 type Class @default.
- NCIT_C103826 isDefinedBy ncit.owl @default.
- NCIT_C103826 label "Taladegib" @default.
- NCIT_C103826 subClassOf NCIT_C103826 @default.
- NCIT_C103826 subClassOf NCIT_C155725 @default.
- NCIT_C103826 subClassOf NCIT_C163758 @default.
- NCIT_C103826 subClassOf NCIT_C188731 @default.
- NCIT_C103826 subClassOf NCIT_C1908 @default.
- NCIT_C103826 subClassOf NCIT_C1909 @default.
- NCIT_C103826 subClassOf NCIT_C2189 @default.
- NCIT_C103826 subClassOf NCIT_C274 @default.