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- NCIT_C1055 IAO_0000115 "The eicosasodium salt of a mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. Custirsen inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance." @default.
- NCIT_C1055 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1055 NCIT_A7 NCIT_C84432 @default.
- NCIT_C1055 NCIT_NHC0 "C1055" @default.
- NCIT_C1055 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C1055 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1055 NCIT_P107 "Custirsen Sodium" @default.
- NCIT_C1055 NCIT_P108 "Custirsen Sodium" @default.
- NCIT_C1055 NCIT_P207 "C1328699" @default.
- NCIT_C1055 NCIT_P210 "685922-56-9" @default.
- NCIT_C1055 NCIT_P319 "ILE26V76EB" @default.
- NCIT_C1055 NCIT_P322 "CTRP" @default.
- NCIT_C1055 NCIT_P322 "FDA" @default.
- NCIT_C1055 NCIT_P322 "GDC" @default.
- NCIT_C1055 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks the production of a protein called clusterin, which helps cells live longer. This may kill cancer cells that need clusterin to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent." @default.
- NCIT_C1055 NCIT_P329 "271195" @default.
- NCIT_C1055 NCIT_P330 "271195" @default.
- NCIT_C1055 NCIT_P350 "C231H292N78O119P20S20.20Na" @default.
- NCIT_C1055 NCIT_P366 "OGX-011" @default.
- NCIT_C1055 NCIT_P375 "Custirsen Sodium" @default.
- NCIT_C1055 NCIT_P399 "271195" @default.
- NCIT_C1055 normalizedInformationContent "100" @default.
- NCIT_C1055 referenceCount "1" @default.
- NCIT_C1055 hasExactSynonym "(3'-5')d(P-thio)([2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-A-G-C-A-G-A-G-T-C-T-T-C-A-[2'-O-(2- methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]m5rU), Eicosasodium Salt" @default.
- NCIT_C1055 hasExactSynonym "Antisense TRPM-2" @default.
- NCIT_C1055 hasExactSynonym "Antisense Testosterone-Repressed Prostate Message 2" @default.
- NCIT_C1055 hasExactSynonym "CUSTIRSEN SODIUM" @default.
- NCIT_C1055 hasExactSynonym "Clusterin Antisense Oligonucleotide" @default.
- NCIT_C1055 hasExactSynonym "Custirsen Sodium" @default.
- NCIT_C1055 hasExactSynonym "ISIS 112989" @default.
- NCIT_C1055 hasExactSynonym "OGX-011" @default.
- NCIT_C1055 hasExactSynonym "TRPM-2 Antisense" @default.
- NCIT_C1055 hasExactSynonym "custirsen sodium" @default.
- NCIT_C1055 inSubset NCIT_C116977 @default.
- NCIT_C1055 inSubset NCIT_C116978 @default.
- NCIT_C1055 inSubset NCIT_C128784 @default.
- NCIT_C1055 inSubset NCIT_C157711 @default.
- NCIT_C1055 inSubset NCIT_C157712 @default.
- NCIT_C1055 inSubset NCIT_C176424 @default.
- NCIT_C1055 inSubset NCIT_C177537 @default.
- NCIT_C1055 inSubset NCIT_C63923 @default.
- NCIT_C1055 type Class @default.
- NCIT_C1055 isDefinedBy ncit.owl @default.
- NCIT_C1055 label "Custirsen Sodium" @default.
- NCIT_C1055 subClassOf NCIT_C1055 @default.
- NCIT_C1055 subClassOf NCIT_C1291 @default.
- NCIT_C1055 subClassOf NCIT_C1908 @default.
- NCIT_C1055 subClassOf NCIT_C1909 @default.
- NCIT_C1055 subClassOf NCIT_C1962 @default.
- NCIT_C1055 subClassOf NCIT_C307 @default.