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- NCIT_C1094 IAO_0000115 "A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. (NCI04)" @default.
- NCIT_C1094 NCIT_A24 NCIT_C274 @default.
- NCIT_C1094 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1094 NCIT_NHC0 "C1094" @default.
- NCIT_C1094 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C1094 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1094 NCIT_P108 "Fludarabine" @default.
- NCIT_C1094 NCIT_P175 "118218" @default.
- NCIT_C1094 NCIT_P207 "C0059985" @default.
- NCIT_C1094 NCIT_P210 "21679-14-1" @default.
- NCIT_C1094 NCIT_P302 "Acute nonlymphocytic leukemia; Chronic lymphocytic leukemia; Indolent Non - Hodkins Lymphoma" @default.
- NCIT_C1094 NCIT_P319 "P2K93U8740" @default.
- NCIT_C1094 NCIT_P322 "FDA" @default.
- NCIT_C1094 NCIT_P322 "GDC" @default.
- NCIT_C1094 NCIT_P322 "PCDC" @default.
- NCIT_C1094 NCIT_P325 "The active ingredient in a drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. Fludarabine blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor." @default.
- NCIT_C1094 NCIT_P350 "C10H12FN5O4" @default.
- NCIT_C1094 NCIT_P366 "Fludarabine" @default.
- NCIT_C1094 NCIT_P375 "Fludarabine" @default.
- NCIT_C1094 normalizedInformationContent "73.131390272436164" @default.
- NCIT_C1094 referenceCount "58" @default.
- NCIT_C1094 hasExactSynonym "2-Fluoro-9-beta-arabinofuranosyladenine" @default.
- NCIT_C1094 hasExactSynonym "2-Fluorovidarabine" @default.
- NCIT_C1094 hasExactSynonym "9-Beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine" @default.
- NCIT_C1094 hasExactSynonym "9-Beta-D-arabinofuranosyl-2-fluoroadenine" @default.
- NCIT_C1094 hasExactSynonym "FLUDARABINE" @default.
- NCIT_C1094 hasExactSynonym "Fludarabine" @default.
- NCIT_C1094 hasExactSynonym "Fluradosa" @default.
- NCIT_C1094 hasExactSynonym "fludarabine" @default.
- NCIT_C1094 inSubset NCIT_C128784 @default.
- NCIT_C1094 inSubset NCIT_C157711 @default.
- NCIT_C1094 inSubset NCIT_C157712 @default.
- NCIT_C1094 inSubset NCIT_C173234 @default.
- NCIT_C1094 inSubset NCIT_C174019 @default.
- NCIT_C1094 inSubset NCIT_C177537 @default.
- NCIT_C1094 inSubset NCIT_C186327 @default.
- NCIT_C1094 inSubset NCIT_C186328 @default.
- NCIT_C1094 inSubset NCIT_C186341 @default.
- NCIT_C1094 inSubset NCIT_C63923 @default.
- NCIT_C1094 type Class @default.
- NCIT_C1094 isDefinedBy ncit.owl @default.
- NCIT_C1094 label "Fludarabine" @default.
- NCIT_C1094 subClassOf NCIT_C1094 @default.
- NCIT_C1094 subClassOf NCIT_C1556 @default.
- NCIT_C1094 subClassOf NCIT_C186664 @default.
- NCIT_C1094 subClassOf NCIT_C1908 @default.
- NCIT_C1094 subClassOf NCIT_C1909 @default.
- NCIT_C1094 subClassOf NCIT_C2150 @default.
- NCIT_C1094 subClassOf NCIT_C272 @default.
- NCIT_C1094 subClassOf NCIT_C274 @default.
- NCIT_C1094 subClassOf NCIT_C471 @default.