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- NCIT_C1212 IAO_0000115 "A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)" @default.
- NCIT_C1212 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1212 NCIT_A7 NCIT_C102485 @default.
- NCIT_C1212 NCIT_A7 NCIT_C38929 @default.
- NCIT_C1212 NCIT_NHC0 "C1212" @default.
- NCIT_C1212 NCIT_P106 "Antibiotic" @default.
- NCIT_C1212 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1212 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1212 NCIT_P107 "Sirolimus" @default.
- NCIT_C1212 NCIT_P108 "Sirolimus" @default.
- NCIT_C1212 NCIT_P175 "226080" @default.
- NCIT_C1212 NCIT_P207 "C0072980" @default.
- NCIT_C1212 NCIT_P210 "53123-88-9" @default.
- NCIT_C1212 NCIT_P302 "Kidney transplant rejection, prevention" @default.
- NCIT_C1212 NCIT_P319 "W36ZG6FT64" @default.
- NCIT_C1212 NCIT_P322 "CTRP" @default.
- NCIT_C1212 NCIT_P322 "FDA" @default.
- NCIT_C1212 NCIT_P322 "GDC" @default.
- NCIT_C1212 NCIT_P325 "A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin." @default.
- NCIT_C1212 NCIT_P329 "42555" @default.
- NCIT_C1212 NCIT_P330 "42555" @default.
- NCIT_C1212 NCIT_P350 "C51H79NO13" @default.
- NCIT_C1212 NCIT_P366 "Sirolimus" @default.
- NCIT_C1212 NCIT_P368 "CHEBI:9168" @default.
- NCIT_C1212 NCIT_P375 "Sirolimus" @default.
- NCIT_C1212 NCIT_P399 "42555" @default.
- NCIT_C1212 NCIT_R122 NCIT_C16484 @default.
- NCIT_C1212 NCIT_R122 NCIT_C16486 @default.
- NCIT_C1212 NCIT_R122 NCIT_C16554 @default.
- NCIT_C1212 NCIT_R122 NCIT_C16865 @default.
- NCIT_C1212 NCIT_R122 NCIT_C16946 @default.
- NCIT_C1212 NCIT_R122 NCIT_C17021 @default.
- NCIT_C1212 NCIT_R122 NCIT_C17573 @default.
- NCIT_C1212 NCIT_R122 NCIT_C20027 @default.
- NCIT_C1212 NCIT_R122 NCIT_C26548 @default.
- NCIT_C1212 NCIT_R122 NCIT_C28459 @default.
- NCIT_C1212 NCIT_R122 NCIT_C45999 @default.
- NCIT_C1212 NCIT_R122 NCIT_C46000 @default.
- NCIT_C1212 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C1212 referenceCount "6" @default.
- NCIT_C1212 hasExactSynonym "9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2" @default.
- NCIT_C1212 hasExactSynonym "AY 22989" @default.
- NCIT_C1212 hasExactSynonym "RAPA" @default.
- NCIT_C1212 hasExactSynonym "RAPAMYCIN" @default.
- NCIT_C1212 hasExactSynonym "Rapamune" @default.
- NCIT_C1212 hasExactSynonym "Rapamycin" @default.
- NCIT_C1212 hasExactSynonym "SILA 9268A" @default.
- NCIT_C1212 hasExactSynonym "SIROLIMUS" @default.
- NCIT_C1212 hasExactSynonym "Sirolimus" @default.
- NCIT_C1212 hasExactSynonym "WY-090217" @default.
- NCIT_C1212 hasExactSynonym "rapamycin" @default.
- NCIT_C1212 hasExactSynonym "sirolimus" @default.
- NCIT_C1212 inSubset NCIT_C116977 @default.
- NCIT_C1212 inSubset NCIT_C116978 @default.
- NCIT_C1212 inSubset NCIT_C157711 @default.
- NCIT_C1212 inSubset NCIT_C157712 @default.
- NCIT_C1212 inSubset NCIT_C173381 @default.
- NCIT_C1212 inSubset NCIT_C173383 @default.
- NCIT_C1212 inSubset NCIT_C176424 @default.
- NCIT_C1212 inSubset NCIT_C177537 @default.
- NCIT_C1212 inSubset NCIT_C63923 @default.
- NCIT_C1212 type Class @default.
- NCIT_C1212 isDefinedBy ncit.owl @default.
- NCIT_C1212 label "Sirolimus" @default.
- NCIT_C1212 subClassOf B0ca2e5a5802e78a16acf2ed1a9ecf5ed @default.
- NCIT_C1212 subClassOf B3de37aa6264e9bee305797232ff93bab @default.
- NCIT_C1212 subClassOf B486c439532bd440a26faba8e988cd41b @default.
- NCIT_C1212 subClassOf B51ef8b0c409b41a0e736dcbd741ce989 @default.
- NCIT_C1212 subClassOf B6719567f52c4f9ed8cd78ead2b04e9da @default.
- NCIT_C1212 subClassOf Bad391e0065c3b3a7f2021b172a77a135 @default.
- NCIT_C1212 subClassOf NCIT_C1212 @default.
- NCIT_C1212 subClassOf NCIT_C1404 @default.
- NCIT_C1212 subClassOf NCIT_C163758 @default.
- NCIT_C1212 subClassOf NCIT_C1908 @default.
- NCIT_C1212 subClassOf NCIT_C1909 @default.
- NCIT_C1212 subClassOf NCIT_C2201 @default.
- NCIT_C1212 subClassOf NCIT_C254 @default.
- NCIT_C1212 subClassOf NCIT_C258 @default.
- NCIT_C1212 subClassOf NCIT_C261 @default.
- NCIT_C1212 subClassOf NCIT_C274 @default.
- NCIT_C1212 subClassOf NCIT_C308 @default.
- NCIT_C1212 subClassOf NCIT_C471 @default.
- NCIT_C1212 subClassOf NCIT_C574 @default.
- NCIT_C1212 subClassOf NCIT_C61074 @default.
- NCIT_C1212 subClassOf NCIT_C784 @default.