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- NCIT_C1271 IAO_0000115 "A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04)" @default.
- NCIT_C1271 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1271 NCIT_A7 NCIT_C17017 @default.
- NCIT_C1271 NCIT_A7 NCIT_C17579 @default.
- NCIT_C1271 NCIT_A7 NCIT_C17767 @default.
- NCIT_C1271 NCIT_A7 NCIT_C25919 @default.
- NCIT_C1271 NCIT_A7 NCIT_C41625 @default.
- NCIT_C1271 NCIT_NHC0 "C1271" @default.
- NCIT_C1271 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1271 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1271 NCIT_P107 "7-Hydroxystaurosporine" @default.
- NCIT_C1271 NCIT_P108 "7-Hydroxystaurosporine" @default.
- NCIT_C1271 NCIT_P175 "638850" @default.
- NCIT_C1271 NCIT_P207 "C0077681" @default.
- NCIT_C1271 NCIT_P210 "112953-11-4" @default.
- NCIT_C1271 NCIT_P319 "7BU5H4V94A" @default.
- NCIT_C1271 NCIT_P322 "CTRP" @default.
- NCIT_C1271 NCIT_P322 "FDA" @default.
- NCIT_C1271 NCIT_P322 "GDC" @default.
- NCIT_C1271 NCIT_P325 "An anticancer drug that belongs to the family of drugs called staurosporine analogues." @default.
- NCIT_C1271 NCIT_P329 "42305" @default.
- NCIT_C1271 NCIT_P330 "42305" @default.
- NCIT_C1271 NCIT_P350 "C28H26N4O4" @default.
- NCIT_C1271 NCIT_P366 "_7-Hydroxystaurosporine" @default.
- NCIT_C1271 NCIT_P375 "7-Hydroxystaurosporine" @default.
- NCIT_C1271 NCIT_P399 "42305" @default.
- NCIT_C1271 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1271 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1271 NCIT_R124 NCIT_C28498 @default.
- NCIT_C1271 NCIT_R124 NCIT_C40576 @default.
- NCIT_C1271 NCIT_R124 NCIT_C40577 @default.
- NCIT_C1271 NCIT_R125 NCIT_C16397 @default.
- NCIT_C1271 NCIT_R125 NCIT_C16513 @default.
- NCIT_C1271 NCIT_R125 NCIT_C16750 @default.
- NCIT_C1271 NCIT_R125 NCIT_C17710 @default.
- NCIT_C1271 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1271 NCIT_R125 NCIT_C18300 @default.
- NCIT_C1271 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1271 NCIT_R125 NCIT_C21102 @default.
- NCIT_C1271 NCIT_R125 NCIT_C21230 @default.
- NCIT_C1271 NCIT_R125 NCIT_C25868 @default.
- NCIT_C1271 NCIT_R125 NCIT_C28498 @default.
- NCIT_C1271 NCIT_R125 NCIT_C40661 @default.
- NCIT_C1271 NCIT_R125 NCIT_C40662 @default.
- NCIT_C1271 NCIT_R125 NCIT_C41543 @default.
- NCIT_C1271 NCIT_R146 NCIT_C16554 @default.
- NCIT_C1271 NCIT_R146 NCIT_C16984 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17017 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17018 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17021 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17210 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17325 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17579 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17761 @default.
- NCIT_C1271 NCIT_R146 NCIT_C17767 @default.
- NCIT_C1271 NCIT_R146 NCIT_C18466 @default.
- NCIT_C1271 NCIT_R146 NCIT_C20027 @default.
- NCIT_C1271 NCIT_R146 NCIT_C21176 @default.
- NCIT_C1271 NCIT_R146 NCIT_C25919 @default.
- NCIT_C1271 NCIT_R146 NCIT_C26548 @default.
- NCIT_C1271 NCIT_R146 NCIT_C41625 @default.
- NCIT_C1271 normalizedInformationContent "84.132738204908478" @default.
- NCIT_C1271 referenceCount "11" @default.
- NCIT_C1271 hasExactSynonym "(+)-UCN-01" @default.
- NCIT_C1271 hasExactSynonym "2,3,9,10,11,12-Hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one" @default.
- NCIT_C1271 hasExactSynonym "7-HYDROXYSTAUROSPORINE" @default.
- NCIT_C1271 hasExactSynonym "7-Hydroxy-staurosporine" @default.
- NCIT_C1271 hasExactSynonym "7-Hydroxystaurosporine" @default.
- NCIT_C1271 hasExactSynonym "8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)" @default.
- NCIT_C1271 hasExactSynonym "UCN-01" @default.
- NCIT_C1271 inSubset NCIT_C116977 @default.
- NCIT_C1271 inSubset NCIT_C116978 @default.
- NCIT_C1271 inSubset NCIT_C128784 @default.
- NCIT_C1271 inSubset NCIT_C157711 @default.
- NCIT_C1271 inSubset NCIT_C157712 @default.
- NCIT_C1271 inSubset NCIT_C176424 @default.
- NCIT_C1271 inSubset NCIT_C177537 @default.
- NCIT_C1271 inSubset NCIT_C63923 @default.
- NCIT_C1271 type Class @default.
- NCIT_C1271 isDefinedBy ncit.owl @default.
- NCIT_C1271 label "7-Hydroxystaurosporine" @default.
- NCIT_C1271 subClassOf NCIT_C1271 @default.
- NCIT_C1271 subClassOf NCIT_C1404 @default.
- NCIT_C1271 subClassOf NCIT_C1908 @default.
- NCIT_C1271 subClassOf NCIT_C1909 @default.
- NCIT_C1271 subClassOf NCIT_C471 @default.
- NCIT_C1271 equivalentClass B4a0fa3a7d13484706eb40b02e2b8c556 @default.
- NCIT_C1271 equivalentClass Ba57f0439c16943a2f11090e89928741c @default.