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- NCIT_C1282 IAO_0000115 "A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)" @default.
- NCIT_C1282 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1282 NCIT_A33 NCIT_C274 @default.
- NCIT_C1282 NCIT_NHC0 "C1282" @default.
- NCIT_C1282 NCIT_P106 "Inorganic Chemical" @default.
- NCIT_C1282 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1282 NCIT_P107 "Carboplatin" @default.
- NCIT_C1282 NCIT_P108 "Carboplatin" @default.
- NCIT_C1282 NCIT_P175 "201345" @default.
- NCIT_C1282 NCIT_P175 "241240" @default.
- NCIT_C1282 NCIT_P207 "C0079083" @default.
- NCIT_C1282 NCIT_P210 "41575-94-4" @default.
- NCIT_C1282 NCIT_P302 "Osteogenic sarcoma; CNS and germ cell tumors; ovarian; lung; head and neck; endometrial; esophageal; bladder; breast; cervical cancer." @default.
- NCIT_C1282 NCIT_P319 "BG3F62OND5" @default.
- NCIT_C1282 NCIT_P322 "CTRP" @default.
- NCIT_C1282 NCIT_P322 "FDA" @default.
- NCIT_C1282 NCIT_P322 "GDC" @default.
- NCIT_C1282 NCIT_P322 "OORO" @default.
- NCIT_C1282 NCIT_P322 "PCDC" @default.
- NCIT_C1282 NCIT_P325 "A drug that is used to treat advanced ovarian cancer that has never been treated or symptoms of ovarian cancer that has come back after treatment with other anticancer drugs. It is also used with other drugs to treat advanced, metastatic, or recurrent non-small cell lung cancer and is being studied in the treatment of other types of cancer. Paraplatin is a form of the anticancer drug cisplatin and causes fewer side effects in patients. It attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound." @default.
- NCIT_C1282 NCIT_P329 "39176" @default.
- NCIT_C1282 NCIT_P330 "39176" @default.
- NCIT_C1282 NCIT_P350 "C6H6O4.Pt.2H3N" @default.
- NCIT_C1282 NCIT_P366 "Carboplatin" @default.
- NCIT_C1282 NCIT_P368 "CHEBI:31355" @default.
- NCIT_C1282 NCIT_P375 "Carboplatin" @default.
- NCIT_C1282 NCIT_P399 "39176" @default.
- NCIT_C1282 normalizedInformationContent "62.390831190720071" @default.
- NCIT_C1282 referenceCount "294" @default.
- NCIT_C1282 hasExactSynonym "(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum" @default.
- NCIT_C1282 hasExactSynonym "1,1-cyclobutanedicarboxylic acid platinum complex" @default.
- NCIT_C1282 hasExactSynonym "Blastocarb" @default.
- NCIT_C1282 hasExactSynonym "CARBOPLATIN" @default.
- NCIT_C1282 hasExactSynonym "CBDCA" @default.
- NCIT_C1282 hasExactSynonym "Carboplat" @default.
- NCIT_C1282 hasExactSynonym "Carboplatin Hexal" @default.
- NCIT_C1282 hasExactSynonym "Carboplatin" @default.
- NCIT_C1282 hasExactSynonym "Carboplatino" @default.
- NCIT_C1282 hasExactSynonym "Carboplatinum" @default.
- NCIT_C1282 hasExactSynonym "Carbosin" @default.
- NCIT_C1282 hasExactSynonym "Carbosol" @default.
- NCIT_C1282 hasExactSynonym "Carbotec" @default.
- NCIT_C1282 hasExactSynonym "Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum" @default.
- NCIT_C1282 hasExactSynonym "Displata" @default.
- NCIT_C1282 hasExactSynonym "Ercar" @default.
- NCIT_C1282 hasExactSynonym "JM-8" @default.
- NCIT_C1282 hasExactSynonym "JM8" @default.
- NCIT_C1282 hasExactSynonym "Nealorin" @default.
- NCIT_C1282 hasExactSynonym "Novoplatinum" @default.
- NCIT_C1282 hasExactSynonym "Paraplat" @default.
- NCIT_C1282 hasExactSynonym "Paraplatin AQ" @default.
- NCIT_C1282 hasExactSynonym "Paraplatin" @default.
- NCIT_C1282 hasExactSynonym "Paraplatine" @default.
- NCIT_C1282 hasExactSynonym "Platinwas" @default.
- NCIT_C1282 hasExactSynonym "Ribocarbo" @default.
- NCIT_C1282 hasExactSynonym "carboplatin" @default.
- NCIT_C1282 hasExactSynonym "cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)" @default.
- NCIT_C1282 hasExactSynonym "cis-diammine(cyclobutanedicarboxylato)platinum II" @default.
- NCIT_C1282 hasExactSynonym "platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)" @default.
- NCIT_C1282 inSubset NCIT_C116977 @default.
- NCIT_C1282 inSubset NCIT_C116978 @default.
- NCIT_C1282 inSubset NCIT_C128784 @default.
- NCIT_C1282 inSubset NCIT_C157711 @default.
- NCIT_C1282 inSubset NCIT_C157712 @default.
- NCIT_C1282 inSubset NCIT_C176424 @default.
- NCIT_C1282 inSubset NCIT_C177383 @default.
- NCIT_C1282 inSubset NCIT_C177406 @default.
- NCIT_C1282 inSubset NCIT_C177537 @default.
- NCIT_C1282 inSubset NCIT_C179478 @default.
- NCIT_C1282 inSubset NCIT_C179531 @default.
- NCIT_C1282 inSubset NCIT_C186327 @default.
- NCIT_C1282 inSubset NCIT_C186328 @default.
- NCIT_C1282 inSubset NCIT_C186341 @default.
- NCIT_C1282 inSubset NCIT_C192234 @default.
- NCIT_C1282 inSubset NCIT_C63923 @default.
- NCIT_C1282 type Class @default.
- NCIT_C1282 isDefinedBy ncit.owl @default.
- NCIT_C1282 label "Carboplatin" @default.
- NCIT_C1282 subClassOf NCIT_C1282 @default.
- NCIT_C1282 subClassOf NCIT_C1450 @default.
- NCIT_C1282 subClassOf NCIT_C1590 @default.
- NCIT_C1282 subClassOf NCIT_C186664 @default.
- NCIT_C1282 subClassOf NCIT_C1908 @default.
- NCIT_C1282 subClassOf NCIT_C1909 @default.
- NCIT_C1282 subClassOf NCIT_C2163 @default.
- NCIT_C1282 subClassOf NCIT_C274 @default.
- NCIT_C1282 subClassOf NCIT_C2842 @default.
- NCIT_C1282 subClassOf NCIT_C798 @default.