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- NCIT_C1311 IAO_0000115 "A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent." @default.
- NCIT_C1311 NCIT_A7 NCIT_C17275 @default.
- NCIT_C1311 NCIT_NHC0 "C1311" @default.
- NCIT_C1311 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1311 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1311 NCIT_P107 "Tacrolimus" @default.
- NCIT_C1311 NCIT_P108 "Tacrolimus" @default.
- NCIT_C1311 NCIT_P175 "717865" @default.
- NCIT_C1311 NCIT_P207 "C0085149" @default.
- NCIT_C1311 NCIT_P210 "109581-93-3" @default.
- NCIT_C1311 NCIT_P302 "Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis" @default.
- NCIT_C1311 NCIT_P319 "WM0HAQ4WNM" @default.
- NCIT_C1311 NCIT_P322 "CTRP" @default.
- NCIT_C1311 NCIT_P322 "FDA" @default.
- NCIT_C1311 NCIT_P325 "A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants." @default.
- NCIT_C1311 NCIT_P329 "42009" @default.
- NCIT_C1311 NCIT_P330 "42009" @default.
- NCIT_C1311 NCIT_P350 "C44H69NO12.H2O" @default.
- NCIT_C1311 NCIT_P366 "Tacrolimus" @default.
- NCIT_C1311 NCIT_P368 "CHEBI:61057" @default.
- NCIT_C1311 NCIT_P399 "42009" @default.
- NCIT_C1311 NCIT_R122 NCIT_C16484 @default.
- NCIT_C1311 NCIT_R122 NCIT_C16486 @default.
- NCIT_C1311 NCIT_R122 NCIT_C16554 @default.
- NCIT_C1311 NCIT_R122 NCIT_C16865 @default.
- NCIT_C1311 NCIT_R122 NCIT_C16946 @default.
- NCIT_C1311 NCIT_R122 NCIT_C17021 @default.
- NCIT_C1311 NCIT_R122 NCIT_C17573 @default.
- NCIT_C1311 NCIT_R122 NCIT_C20027 @default.
- NCIT_C1311 NCIT_R122 NCIT_C26548 @default.
- NCIT_C1311 NCIT_R122 NCIT_C28459 @default.
- NCIT_C1311 NCIT_R122 NCIT_C45999 @default.
- NCIT_C1311 NCIT_R122 NCIT_C46000 @default.
- NCIT_C1311 normalizedInformationContent "82.536929774922015" @default.
- NCIT_C1311 referenceCount "14" @default.
- NCIT_C1311 hasExactSynonym "FK 506" @default.
- NCIT_C1311 hasExactSynonym "FK-506" @default.
- NCIT_C1311 hasExactSynonym "Fujimycin" @default.
- NCIT_C1311 hasExactSynonym "Hecoria" @default.
- NCIT_C1311 hasExactSynonym "Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone" @default.
- NCIT_C1311 hasExactSynonym "Prograf" @default.
- NCIT_C1311 hasExactSynonym "Protopic" @default.
- NCIT_C1311 hasExactSynonym "TACROLIMUS" @default.
- NCIT_C1311 hasExactSynonym "Tacforius" @default.
- NCIT_C1311 hasExactSynonym "Tacrolimus" @default.
- NCIT_C1311 hasExactSynonym "tacrolimus" @default.
- NCIT_C1311 inSubset NCIT_C116977 @default.
- NCIT_C1311 inSubset NCIT_C116978 @default.
- NCIT_C1311 inSubset NCIT_C173381 @default.
- NCIT_C1311 inSubset NCIT_C173383 @default.
- NCIT_C1311 inSubset NCIT_C176424 @default.
- NCIT_C1311 inSubset NCIT_C63923 @default.
- NCIT_C1311 type Class @default.
- NCIT_C1311 isDefinedBy ncit.owl @default.
- NCIT_C1311 label "Tacrolimus" @default.
- NCIT_C1311 subClassOf B4d0e92071c07262f5aefb384ebbeacb7 @default.
- NCIT_C1311 subClassOf Bb7f981a4e2e14c8501cdf238fdc69a93 @default.
- NCIT_C1311 subClassOf Bc0394c573c51615cbb3f6e096502435d @default.
- NCIT_C1311 subClassOf Bdb3bb3ad6f10e68215623d39919f35c0 @default.
- NCIT_C1311 subClassOf Bdc7ec392e81582314ac1c9d9544b2763 @default.
- NCIT_C1311 subClassOf Be8b9c41812fbff3609d65cf0e06c8897 @default.
- NCIT_C1311 subClassOf NCIT_C1311 @default.
- NCIT_C1311 subClassOf NCIT_C146638 @default.
- NCIT_C1311 subClassOf NCIT_C1908 @default.
- NCIT_C1311 subClassOf NCIT_C1909 @default.
- NCIT_C1311 subClassOf NCIT_C308 @default.
- NCIT_C1311 subClassOf NCIT_C574 @default.