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- NCIT_C1333 IAO_0000115 "A bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition." @default.
- NCIT_C1333 NCIT_A24 NCIT_C70902 @default.
- NCIT_C1333 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1333 NCIT_A5 NCIT_C66945 @default.
- NCIT_C1333 NCIT_NHC0 "C1333" @default.
- NCIT_C1333 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1333 NCIT_P107 "Dexrazoxane" @default.
- NCIT_C1333 NCIT_P108 "Dexrazoxane" @default.
- NCIT_C1333 NCIT_P175 "169780" @default.
- NCIT_C1333 NCIT_P207 "C0086444" @default.
- NCIT_C1333 NCIT_P210 "24584-09-6" @default.
- NCIT_C1333 NCIT_P302 "Chemotherapy-induced cardiomyopathy" @default.
- NCIT_C1333 NCIT_P319 "048L81261F" @default.
- NCIT_C1333 NCIT_P322 "CTRP" @default.
- NCIT_C1333 NCIT_P322 "FDA" @default.
- NCIT_C1333 NCIT_P322 "GDC" @default.
- NCIT_C1333 NCIT_P322 "PCDC" @default.
- NCIT_C1333 NCIT_P325 "The active ingredient in a drug used to treat severe side effects caused by certain anticancer drugs. Under the brand name Totect it is used to treat the toxic effects of an anticancer drug that leaks from a vein into surrounding tissue and causes tissue damage. Under the brand name Zinecard it is used to reduce heart damage in women given doxorubicin for breast cancer that has spread. Dexrazoxane is also being studied in the treatment of cancer. It is a type of cardioprotective agent, a type of chemoprotective agent, and a type of topoisomerase inhibitor." @default.
- NCIT_C1333 NCIT_P350 "C11H16N4O4" @default.
- NCIT_C1333 NCIT_P366 "Dexrazoxane" @default.
- NCIT_C1333 NCIT_P368 "CHEBI:50223" @default.
- NCIT_C1333 NCIT_P375 "Dexrazoxane" @default.
- NCIT_C1333 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1333 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1333 NCIT_R124 NCIT_C18219 @default.
- NCIT_C1333 NCIT_R124 NCIT_C19426 @default.
- NCIT_C1333 NCIT_R124 NCIT_C19986 @default.
- NCIT_C1333 NCIT_R124 NCIT_C40483 @default.
- NCIT_C1333 NCIT_R124 NCIT_C40516 @default.
- NCIT_C1333 NCIT_R125 NCIT_C17710 @default.
- NCIT_C1333 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1333 NCIT_R125 NCIT_C19536 @default.
- NCIT_C1333 NCIT_R125 NCIT_C28498 @default.
- NCIT_C1333 NCIT_R125 NCIT_C40576 @default.
- NCIT_C1333 NCIT_R125 NCIT_C40577 @default.
- NCIT_C1333 NCIT_R125 NCIT_C41583 @default.
- NCIT_C1333 NCIT_R125 NCIT_C41584 @default.
- NCIT_C1333 normalizedInformationContent "81.653330900245635" @default.
- NCIT_C1333 referenceCount "16" @default.
- NCIT_C1333 hasExactSynonym "(+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione)" @default.
- NCIT_C1333 hasExactSynonym "2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI)" @default.
- NCIT_C1333 hasExactSynonym "2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI)" @default.
- NCIT_C1333 hasExactSynonym "2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-(9CI)" @default.
- NCIT_C1333 hasExactSynonym "2,6-Piperazinedione, 4,4'propylenedi-,(P)-(8CI)" @default.
- NCIT_C1333 hasExactSynonym "ADR-529" @default.
- NCIT_C1333 hasExactSynonym "DEXRAZOXANE" @default.
- NCIT_C1333 hasExactSynonym "Dexrazoxane" @default.
- NCIT_C1333 hasExactSynonym "ICRF-187" @default.
- NCIT_C1333 hasExactSynonym "Razoxane (+)-form" @default.
- NCIT_C1333 hasExactSynonym "Soluble ICRF (L-isomer)" @default.
- NCIT_C1333 hasExactSynonym "dexrazoxane" @default.
- NCIT_C1333 inSubset NCIT_C116977 @default.
- NCIT_C1333 inSubset NCIT_C116978 @default.
- NCIT_C1333 inSubset NCIT_C128784 @default.
- NCIT_C1333 inSubset NCIT_C157711 @default.
- NCIT_C1333 inSubset NCIT_C157712 @default.
- NCIT_C1333 inSubset NCIT_C173243 @default.
- NCIT_C1333 inSubset NCIT_C174019 @default.
- NCIT_C1333 inSubset NCIT_C177537 @default.
- NCIT_C1333 inSubset NCIT_C186329 @default.
- NCIT_C1333 inSubset NCIT_C186341 @default.
- NCIT_C1333 inSubset NCIT_C63923 @default.
- NCIT_C1333 type Class @default.
- NCIT_C1333 isDefinedBy ncit.owl @default.
- NCIT_C1333 label "Dexrazoxane" @default.
- NCIT_C1333 subClassOf B03e1f0fccbc03d9b6f8859d2f4f7c9bc @default.
- NCIT_C1333 subClassOf B07cb6d879b679a3beab2ca1c307d5423 @default.
- NCIT_C1333 subClassOf B18cb3afe5bbd0f10f4426c5f73bc5b60 @default.
- NCIT_C1333 subClassOf B1b5e9f456301ee8be4f0236aafb86ce1 @default.
- NCIT_C1333 subClassOf B4b94c05206b6f40ed99b03232dd76292 @default.
- NCIT_C1333 subClassOf Bda7d936984ea168cd3b0ff244f344850 @default.
- NCIT_C1333 subClassOf NCIT_C1333 @default.
- NCIT_C1333 subClassOf NCIT_C1908 @default.
- NCIT_C1333 subClassOf NCIT_C1932 @default.
- NCIT_C1333 subClassOf NCIT_C360 @default.