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- NCIT_C1336 IAO_0000115 "A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)" @default.
- NCIT_C1336 NCIT_A24 NCIT_C274 @default.
- NCIT_C1336 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1336 NCIT_NHC0 "C1336" @default.
- NCIT_C1336 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C1336 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1336 NCIT_P107 "Cladribine" @default.
- NCIT_C1336 NCIT_P108 "Cladribine" @default.
- NCIT_C1336 NCIT_P175 "105014" @default.
- NCIT_C1336 NCIT_P175 "105014-F" @default.
- NCIT_C1336 NCIT_P207 "C0092801" @default.
- NCIT_C1336 NCIT_P210 "4291-63-8" @default.
- NCIT_C1336 NCIT_P302 "Acute myeloid leukemia; Chronic lymphocytic leukemia; Cutaneous T-cell lymphoma; Hairy cell leukemia; Langerhans cell histiocytosis; Non-Hodgkins lymphoma; Waldenstroms macroglobulinemia" @default.
- NCIT_C1336 NCIT_P319 "47M74X9YT5" @default.
- NCIT_C1336 NCIT_P322 "CTRP" @default.
- NCIT_C1336 NCIT_P322 "FDA" @default.
- NCIT_C1336 NCIT_P322 "GDC" @default.
- NCIT_C1336 NCIT_P322 "PCDC" @default.
- NCIT_C1336 NCIT_P325 "An anticancer drug that belongs to the family of drugs called antimetabolites." @default.
- NCIT_C1336 NCIT_P329 "41184" @default.
- NCIT_C1336 NCIT_P330 "41184" @default.
- NCIT_C1336 NCIT_P350 "C10H12ClN5O3" @default.
- NCIT_C1336 NCIT_P366 "Cladribine" @default.
- NCIT_C1336 NCIT_P368 "CHEBI:567361" @default.
- NCIT_C1336 NCIT_P375 "Cladribine" @default.
- NCIT_C1336 NCIT_P399 "41184" @default.
- NCIT_C1336 NCIT_P98 "http://www.cancercare.on.ca/pdfdrugs/Cladribi.pdf" @default.
- NCIT_C1336 normalizedInformationContent "83.556969816060246" @default.
- NCIT_C1336 referenceCount "12" @default.
- NCIT_C1336 hasExactSynonym "2-CdA" @default.
- NCIT_C1336 hasExactSynonym "2-Chloro-2-Deoxyadenosine" @default.
- NCIT_C1336 hasExactSynonym "2-Chlorodeoxyadenosine" @default.
- NCIT_C1336 hasExactSynonym "2CDA" @default.
- NCIT_C1336 hasExactSynonym "CLADRIBINE" @default.
- NCIT_C1336 hasExactSynonym "CdA" @default.
- NCIT_C1336 hasExactSynonym "Cladribina" @default.
- NCIT_C1336 hasExactSynonym "Cladribine" @default.
- NCIT_C1336 hasExactSynonym "Leustat" @default.
- NCIT_C1336 hasExactSynonym "Leustatin" @default.
- NCIT_C1336 hasExactSynonym "Leustatine" @default.
- NCIT_C1336 hasExactSynonym "RWJ-26251" @default.
- NCIT_C1336 hasExactSynonym "cladribine" @default.
- NCIT_C1336 inSubset NCIT_C116977 @default.
- NCIT_C1336 inSubset NCIT_C116978 @default.
- NCIT_C1336 inSubset NCIT_C128784 @default.
- NCIT_C1336 inSubset NCIT_C157711 @default.
- NCIT_C1336 inSubset NCIT_C157712 @default.
- NCIT_C1336 inSubset NCIT_C173234 @default.
- NCIT_C1336 inSubset NCIT_C174019 @default.
- NCIT_C1336 inSubset NCIT_C176424 @default.
- NCIT_C1336 inSubset NCIT_C177537 @default.
- NCIT_C1336 inSubset NCIT_C63923 @default.
- NCIT_C1336 type Class @default.
- NCIT_C1336 isDefinedBy ncit.owl @default.
- NCIT_C1336 label "Cladribine" @default.
- NCIT_C1336 subClassOf NCIT_C1336 @default.
- NCIT_C1336 subClassOf NCIT_C1556 @default.
- NCIT_C1336 subClassOf NCIT_C186664 @default.
- NCIT_C1336 subClassOf NCIT_C1908 @default.
- NCIT_C1336 subClassOf NCIT_C1909 @default.
- NCIT_C1336 subClassOf NCIT_C2157 @default.
- NCIT_C1336 subClassOf NCIT_C272 @default.
- NCIT_C1336 subClassOf NCIT_C274 @default.
- NCIT_C1336 subClassOf NCIT_C471 @default.
- NCIT_C1336 subClassOf NCIT_C798 @default.