FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1036177665> ?p ?o ?g. }

• W1036177665 endingPage "222" @default.
• W1036177665 startingPage "215" @default.
• W1036177665 abstract "Objective: It remains unclear whether antipsychotic polypharmacy, a common clinical practice, is related to an increased risk of corrected time between start of Q wave and end of T wave (QTc) interval prolongation. We conducted a systematic review of the literature to address this important issue. Method: A systematic literature search was conducted in October 2014, using MEDLINE, Embase, and PsycINFO. Studies and case reports were included if they reported QTc intervals or QTc interval changes before and after antipsychotic polypharmacy or QTc intervals in both antipsychotic polypharmacy and monotherapy groups. Results: A total of 21 articles (10 clinical trials, 4 observational studies, and 7 case reports) met inclusion criteria. The clinical trials have shown that a combination treatment with risperidone or pimozide is not obviously related to an increase in QTc interval, whereas ziprasidone or sertindole combined with clozapine may prolong QTc interval. Among the 4 observational studies, antipsychotic polypharmacy was not clearly associated with QTc prolongation in 3 studies, each cross-sectional. In contrast, one prospective study showed a significant increase in QTc interval following antipsychotic coadministration. The case reports indicated an increased risk of QTc prolongation in at least some patients receiving antipsychotic polypharmacy. Conclusions: Currently available evidence fails to confirm that antipsychotic polypharmacy worsens QTc prolongation in general, although the evidence is scarce and inconsistent. Clinicians are advised to remain conservative in resorting to antipsychotic polypharmacy, as a combination of some QTc-prolongation liable antipsychotics may further prolong QTc interval, and efficacy supporting the clinical benefits of antipsychotic polypharmacy is equivocal, at best." @default.
• W1036177665 created "2016-06-24" @default.
• W1036177665 creator A5006005694 @default.
• W1036177665 creator A5021932877 @default.
• W1036177665 creator A5022096029 @default.
• W1036177665 creator A5023791078 @default.
• W1036177665 date "2015-05-01" @default.
• W1036177665 modified "2023-09-26" @default.
• W1036177665 title "Antipsychotic Polypharmacy and Corrected QT Interval: A Systematic Review" @default.
• W1036177665 cites W164923949 @default.
• W1036177665 cites W1835966027 @default.
• W1036177665 cites W1969874681 @default.
• W1036177665 cites W1976303732 @default.
• W1036177665 cites W1979973212 @default.
• W1036177665 cites W1982716212 @default.
• W1036177665 cites W1990734814 @default.
• W1036177665 cites W1996802734 @default.
• W1036177665 cites W1999049281 @default.
• W1036177665 cites W2000285492 @default.
• W1036177665 cites W2004197375 @default.
• W1036177665 cites W2005147855 @default.
• W1036177665 cites W2006427735 @default.
• W1036177665 cites W2007189458 @default.
• W1036177665 cites W2009832071 @default.
• W1036177665 cites W2012458918 @default.
• W1036177665 cites W2012684316 @default.
• W1036177665 cites W2013615650 @default.
• W1036177665 cites W2027681821 @default.
• W1036177665 cites W2028633275 @default.
• W1036177665 cites W2041385263 @default.
• W1036177665 cites W2041862233 @default.
• W1036177665 cites W2044622501 @default.
• W1036177665 cites W2050772825 @default.
• W1036177665 cites W2056706753 @default.
• W1036177665 cites W2059798273 @default.
• W1036177665 cites W2074119907 @default.
• W1036177665 cites W2079869054 @default.
• W1036177665 cites W2094587925 @default.
• W1036177665 cites W2099750676 @default.
• W1036177665 cites W2105507333 @default.
• W1036177665 cites W2107625293 @default.
• W1036177665 cites W2123069664 @default.
• W1036177665 cites W2124060948 @default.
• W1036177665 cites W2125570605 @default.
• W1036177665 cites W2125891235 @default.
• W1036177665 cites W2129132454 @default.
• W1036177665 cites W2132333355 @default.
• W1036177665 cites W2156098321 @default.
• W1036177665 cites W2163259581 @default.
• W1036177665 cites W2425167882 @default.
• W1036177665 cites W2991792334 @default.
• W1036177665 cites W4292004352 @default.
• W1036177665 doi "https://doi.org/10.1177/070674371506000503" @default.
• W1036177665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4484690" @default.
• W1036177665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26174525" @default.
• W1036177665 hasPublicationYear "2015" @default.
• W1036177665 type Work @default.
• W1036177665 sameAs 1036177665 @default.
• W1036177665 citedByCount "60" @default.
• W1036177665 countsByYear W10361776652015 @default.
• W1036177665 countsByYear W10361776652016 @default.
• W1036177665 countsByYear W10361776652017 @default.
• W1036177665 countsByYear W10361776652018 @default.
• W1036177665 countsByYear W10361776652019 @default.
• W1036177665 countsByYear W10361776652020 @default.
• W1036177665 countsByYear W10361776652021 @default.
• W1036177665 countsByYear W10361776652022 @default.
• W1036177665 countsByYear W10361776652023 @default.
• W1036177665 crossrefType "journal-article" @default.
• W1036177665 hasAuthorship W1036177665A5006005694 @default.
• W1036177665 hasAuthorship W1036177665A5021932877 @default.
• W1036177665 hasAuthorship W1036177665A5022096029 @default.
• W1036177665 hasAuthorship W1036177665A5023791078 @default.
• W1036177665 hasBestOaLocation W10361776651 @default.
• W1036177665 hasConcept C118441451 @default.
• W1036177665 hasConcept C118552586 @default.
• W1036177665 hasConcept C126322002 @default.
• W1036177665 hasConcept C177713679 @default.
• W1036177665 hasConcept C23131810 @default.
• W1036177665 hasConcept C2776412080 @default.
• W1036177665 hasConcept C2776619155 @default.
• W1036177665 hasConcept C2777270317 @default.
• W1036177665 hasConcept C2780057945 @default.
• W1036177665 hasConcept C2780494398 @default.
• W1036177665 hasConcept C2780864610 @default.
• W1036177665 hasConcept C2910202354 @default.
• W1036177665 hasConcept C36434225 @default.
• W1036177665 hasConcept C71924100 @default.
• W1036177665 hasConceptScore W1036177665C118441451 @default.
• W1036177665 hasConceptScore W1036177665C118552586 @default.
• W1036177665 hasConceptScore W1036177665C126322002 @default.
• W1036177665 hasConceptScore W1036177665C177713679 @default.
• W1036177665 hasConceptScore W1036177665C23131810 @default.
• W1036177665 hasConceptScore W1036177665C2776412080 @default.
• W1036177665 hasConceptScore W1036177665C2776619155 @default.
• W1036177665 hasConceptScore W1036177665C2777270317 @default.
• W1036177665 hasConceptScore W1036177665C2780057945 @default.
• W1036177665 hasConceptScore W1036177665C2780494398 @default.

• next