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- W1036691286 endingPage "61" @default.
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- W1036691286 abstract "The chapter discusses the various properties of the adenoviruses, such as the nature of virion and the controlling factors in the productive or abortive infection. The dissection of the virion and its component parts, summarized in this chapter, has provided essential markers for the exploration and correlation of these biological variables, the mapping of phage chromosomes, based on deletions in conditional lethal mutants, required the structural and functional identification of phage precursors and subunits, such that each identifiable moiety of the adenovirion will help in relating biological activity to structural and molecular properties of the viral genomes. For a full understanding of the biology of adenovirus infection, as of other virus-cell systems, it is important to recognize that uniformity and synchrony of response is a deliberately created experimental artifact resulting only from high multiplicity infection of competent cells. This type of response may be absent in natural infections, which does not occur under conditions of low multiplicity infection, and may be fundamentally irrelevant in adenoviral tumorigenesis and abortive infection. For the sake of simplicity, any infection with complete adenovirus particles not leading to production of infectious progeny will be defined as “abortive.” The term “complete” in this context, implies that the same virions can induce productive infection in some suitable indicator cell. Hence, these viruses can be characterized, operationally, as host dependent conditionally lethal, either the permissive host cell supplies some function needed for virus replication that the non permissive cell lacks, or the latter imposes a restriction not present in the permissive one. Both alternatives could, in a purely descriptive way, satisfy the need for working hypotheses to explain the various examples of abortive infection with adenoviruses." @default.
- W1036691286 created "2016-06-24" @default.
- W1036691286 creator A5071727305 @default.
- W1036691286 date "1969-01-01" @default.
- W1036691286 modified "2023-09-23" @default.
- W1036691286 title "Adenoviruses: The Nature of the Virion and of Controlling Factors in Productive or Abortive Infection and Tumorigenesis" @default.
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