Matches in SemOpenAlex for { <https://semopenalex.org/work/W129825933> ?p ?o ?g. }
- W129825933 endingPage "57" @default.
- W129825933 startingPage "45" @default.
- W129825933 abstract "The cloning of IL-6 cDNA in 1986 revealed that IL-6 is a multifunctional cytokine that plays important roles in the immunopathogenesis of rheumatoid arthritis (RA). A close relationship was observed between IL-6 levels in the synovial compartment and disease activity in RA patients, and overproduction of IL-6 could readily explain the abnormal laboratory findings and clinical symptoms seen in these patients. IL-6 therefore appeared to be a worthwhile and attractive therapeutic target for RA. In practice, blockage of IL-6 signalling by a humanised anti-IL-6 receptor antibody [tocilizumab (TCZ); also known as MRA] has been found to be very effective in the treatment of patients with RA. In recent Japanese Phase III clinical studies in RA patients, TCZ clearly prevented radiographic progression of joint destruction and greatly improved signs and symptoms. Very interestingly and importantly, this therapy has also proved quite effective at improving fever, fatigue and anaemia. No serious adverse events have been reported. At present, several international clinical studies of TCZ are ongoing in more than 4000 patients with active RA in 41 countries. The results are continuing to confirm the efficacy and safety of TCZ in the treatment of patients with RA." @default.
- W129825933 created "2016-06-24" @default.
- W129825933 creator A5021463605 @default.
- W129825933 creator A5035512198 @default.
- W129825933 date "2009-01-01" @default.
- W129825933 modified "2023-09-26" @default.
- W129825933 title "Immunobiology of IL-6 — Tocilizumab (humanised anti-IL-6 receptor antibody) for the treatment of rheumatoid arthritis" @default.
- W129825933 cites W1576318972 @default.
- W129825933 cites W1632068222 @default.
- W129825933 cites W1968814677 @default.
- W129825933 cites W1971615288 @default.
- W129825933 cites W1971908211 @default.
- W129825933 cites W1975773833 @default.
- W129825933 cites W1979299941 @default.
- W129825933 cites W1983224547 @default.
- W129825933 cites W1992880469 @default.
- W129825933 cites W1996548067 @default.
- W129825933 cites W1999821753 @default.
- W129825933 cites W2000846863 @default.
- W129825933 cites W2002053829 @default.
- W129825933 cites W2002076761 @default.
- W129825933 cites W2004088884 @default.
- W129825933 cites W2007286170 @default.
- W129825933 cites W2017223857 @default.
- W129825933 cites W2022713850 @default.
- W129825933 cites W2026274426 @default.
- W129825933 cites W2032848182 @default.
- W129825933 cites W2035505806 @default.
- W129825933 cites W2036452124 @default.
- W129825933 cites W2043590802 @default.
- W129825933 cites W2045590518 @default.
- W129825933 cites W2046957298 @default.
- W129825933 cites W2049827120 @default.
- W129825933 cites W2055928479 @default.
- W129825933 cites W2059080581 @default.
- W129825933 cites W2063407488 @default.
- W129825933 cites W2066246367 @default.
- W129825933 cites W2066385294 @default.
- W129825933 cites W2067761476 @default.
- W129825933 cites W2097939870 @default.
- W129825933 cites W2112866067 @default.
- W129825933 cites W2125212735 @default.
- W129825933 cites W2133797784 @default.
- W129825933 cites W2135146086 @default.
- W129825933 cites W2139339400 @default.
- W129825933 cites W2150952126 @default.
- W129825933 cites W2153145418 @default.
- W129825933 cites W2155779547 @default.
- W129825933 cites W2171799063 @default.
- W129825933 cites W2776663677 @default.
- W129825933 cites W4232137220 @default.
- W129825933 cites W4234924147 @default.
- W129825933 cites W4245868295 @default.
- W129825933 cites W4249150518 @default.
- W129825933 cites W4361745356 @default.
- W129825933 doi "https://doi.org/10.1007/978-3-7643-8238-4_3" @default.
- W129825933 hasPublicationYear "2009" @default.
- W129825933 type Work @default.
- W129825933 sameAs 129825933 @default.
- W129825933 citedByCount "0" @default.
- W129825933 crossrefType "book-chapter" @default.
- W129825933 hasAuthorship W129825933A5021463605 @default.
- W129825933 hasAuthorship W129825933A5035512198 @default.
- W129825933 hasConcept C11988809 @default.
- W129825933 hasConcept C126322002 @default.
- W129825933 hasConcept C159654299 @default.
- W129825933 hasConcept C197934379 @default.
- W129825933 hasConcept C198451711 @default.
- W129825933 hasConcept C203014093 @default.
- W129825933 hasConcept C2777178219 @default.
- W129825933 hasConcept C2777575956 @default.
- W129825933 hasConcept C2778690821 @default.
- W129825933 hasConcept C71924100 @default.
- W129825933 hasConceptScore W129825933C11988809 @default.
- W129825933 hasConceptScore W129825933C126322002 @default.
- W129825933 hasConceptScore W129825933C159654299 @default.
- W129825933 hasConceptScore W129825933C197934379 @default.
- W129825933 hasConceptScore W129825933C198451711 @default.
- W129825933 hasConceptScore W129825933C203014093 @default.
- W129825933 hasConceptScore W129825933C2777178219 @default.
- W129825933 hasConceptScore W129825933C2777575956 @default.
- W129825933 hasConceptScore W129825933C2778690821 @default.
- W129825933 hasConceptScore W129825933C71924100 @default.
- W129825933 hasLocation W1298259331 @default.
- W129825933 hasOpenAccess W129825933 @default.
- W129825933 hasPrimaryLocation W1298259331 @default.
- W129825933 hasRelatedWork W1984273828 @default.
- W129825933 hasRelatedWork W1987294331 @default.
- W129825933 hasRelatedWork W2035343580 @default.
- W129825933 hasRelatedWork W2046399730 @default.
- W129825933 hasRelatedWork W2134133792 @default.
- W129825933 hasRelatedWork W2232273633 @default.
- W129825933 hasRelatedWork W2558297493 @default.
- W129825933 hasRelatedWork W2736593664 @default.
- W129825933 hasRelatedWork W3027210704 @default.
- W129825933 hasRelatedWork W4232087861 @default.
- W129825933 isParatext "false" @default.
- W129825933 isRetracted "false" @default.