Matches in SemOpenAlex for { <https://semopenalex.org/work/W133064382> ?p ?o ?g. }
- W133064382 endingPage "63" @default.
- W133064382 startingPage "47" @default.
- W133064382 abstract "Despite improvements in the care of asphyxiated neonates, neonatal or perinatal hypoxia-ischemia remains a challenge to clinical practitioners. In this multisystem dysfunction, hypoxic-ischemic encephalopathy contributes to short- and long-term morbidity of these critically ill neonates. In the developing brain of premature and term neonates, there are immature responses to hypoxia-ischemia in the context of selective vulnerability of different brain structures and neural cells at different stages of development. This difference explains at least in part the diversity of clinical presentations and sequelae of neonatal hypoxic-ischemic brain injury. In addition to hypoxic-ischemic damage, cerebral reoxygenation or reperfusion injury plays an important role in the pathophysiology of hypoxic-ischemic brain injury. Mechanisms of cell death and apoptosis operate at multiple levels including oxygen-derived free radical damage and excitotoxicity. Cerebral oxidative stress and neurochemical changes are related in hypoxia-ischemia of the neonatal brain. Controlled reoxygenation to avoid hyperoxia and its related cerebral damage, and novel antioxidative agents such as N-acetylcysteine, are potential therapeutic interventions that may show promise in the improvement of clinical outcome of these asphyxiated neonates with cerebral hypoxic-ischemic injury. The effects of controlled reoxygenation and N-acetylcysteine on the neurochemistry of asphyxiated neonatal brain are discussed." @default.
- W133064382 created "2016-06-24" @default.
- W133064382 creator A5003472896 @default.
- W133064382 creator A5040748132 @default.
- W133064382 creator A5061786933 @default.
- W133064382 date "2010-10-13" @default.
- W133064382 modified "2023-09-26" @default.
- W133064382 title "Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy" @default.
- W133064382 cites W123675495 @default.
- W133064382 cites W126490209 @default.
- W133064382 cites W1519106160 @default.
- W133064382 cites W1543554996 @default.
- W133064382 cites W1563752653 @default.
- W133064382 cites W1576660568 @default.
- W133064382 cites W1637593069 @default.
- W133064382 cites W1734082729 @default.
- W133064382 cites W1793531678 @default.
- W133064382 cites W1896545635 @default.
- W133064382 cites W1901072277 @default.
- W133064382 cites W1930275516 @default.
- W133064382 cites W1930405521 @default.
- W133064382 cites W1964796026 @default.
- W133064382 cites W1967257408 @default.
- W133064382 cites W1972090907 @default.
- W133064382 cites W1973274253 @default.
- W133064382 cites W1980461903 @default.
- W133064382 cites W1985111805 @default.
- W133064382 cites W1986118588 @default.
- W133064382 cites W1986330887 @default.
- W133064382 cites W1992385568 @default.
- W133064382 cites W1996716971 @default.
- W133064382 cites W1998266737 @default.
- W133064382 cites W1999549953 @default.
- W133064382 cites W2000411582 @default.
- W133064382 cites W2002553033 @default.
- W133064382 cites W2005681962 @default.
- W133064382 cites W2007643195 @default.
- W133064382 cites W2007864688 @default.
- W133064382 cites W2016066239 @default.
- W133064382 cites W2017886904 @default.
- W133064382 cites W2018054309 @default.
- W133064382 cites W2018788563 @default.
- W133064382 cites W2019467923 @default.
- W133064382 cites W2019548033 @default.
- W133064382 cites W2020631445 @default.
- W133064382 cites W2024007859 @default.
- W133064382 cites W2024945446 @default.
- W133064382 cites W2027236019 @default.
- W133064382 cites W2027586059 @default.
- W133064382 cites W2027792516 @default.
- W133064382 cites W2031961419 @default.
- W133064382 cites W2033800625 @default.
- W133064382 cites W2036726644 @default.
- W133064382 cites W2037408045 @default.
- W133064382 cites W2039188961 @default.
- W133064382 cites W2041224810 @default.
- W133064382 cites W2041249574 @default.
- W133064382 cites W2045180954 @default.
- W133064382 cites W2048044168 @default.
- W133064382 cites W2051083217 @default.
- W133064382 cites W2054244497 @default.
- W133064382 cites W2061526431 @default.
- W133064382 cites W2061827507 @default.
- W133064382 cites W2066215889 @default.
- W133064382 cites W2067670378 @default.
- W133064382 cites W2073240232 @default.
- W133064382 cites W2073379012 @default.
- W133064382 cites W2075894586 @default.
- W133064382 cites W2076419133 @default.
- W133064382 cites W2077386507 @default.
- W133064382 cites W2079527302 @default.
- W133064382 cites W2082580274 @default.
- W133064382 cites W2086144679 @default.
- W133064382 cites W2091653674 @default.
- W133064382 cites W2092490162 @default.
- W133064382 cites W2098865088 @default.
- W133064382 cites W2102870521 @default.
- W133064382 cites W2105388675 @default.
- W133064382 cites W2109129636 @default.
- W133064382 cites W2113256963 @default.
- W133064382 cites W2117770051 @default.
- W133064382 cites W2120967128 @default.
- W133064382 cites W2126118287 @default.
- W133064382 cites W2127091487 @default.
- W133064382 cites W2128360784 @default.
- W133064382 cites W2132559053 @default.
- W133064382 cites W2132870100 @default.
- W133064382 cites W2135776201 @default.
- W133064382 cites W2141212074 @default.
- W133064382 cites W2142716454 @default.
- W133064382 cites W2144454929 @default.
- W133064382 cites W2144918294 @default.
- W133064382 cites W2145912471 @default.
- W133064382 cites W2146972564 @default.
- W133064382 cites W2155135349 @default.
- W133064382 cites W2160835393 @default.
- W133064382 cites W2161583104 @default.
- W133064382 cites W2169079203 @default.