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- W137431094 abstract "With their wide excursions of body temperature, mammalian hibernators are well suited for studying temperature effects on enzymatic reaction rates, on acid-base state and pH-dependent enzymes, and on membrane fluidity, as well as the corresponding adaptations. Hibernators differ from eurythermic ectotherms however by being torpid when cold and by the fact that the body temperature drop is controlled and reversible. Rewarming is endothermic and from deep hibernation to peak arousal thermogenesis a fiftyfold variation of metabolic rate may occur, for the same body temperature. This reinforces the need for adaptation to a variable body temperature as found in ectotherms: synthesis of isozymes featuring linear Arrhenius plots and constant Km's over the temperature range, and changes in membrane lipid composition (not considered in this paper). Superimposed on the general effect of temperature on enzymatic reaction rates, a further reduction in metabolic rate takes place in hibernation. Ectotherms adjust to the temperature effects on acid-base state by keeping a constant dissociation ratio (alpha) of protein imidazole buffer groups; this minimizes temperature effects on pH-dependent enzymes. In hibernators temperature effects are further complicated by a respiratory acidosis, both extra- and intracellular. In heart and liver, however, ionic compensations restore a constant alpha imidazole in spite of the high PCO2. Tne acidosis is likely to determine or at least to contribute to the inhibition of metabolic rate. Other examples of acidotic torpidity — with this combination of metabolic inhibition and respiratory acidosis — are found in a variety of Vertebrates: lungfish, reptiles and birds." @default.
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- W137431094 date "1980-01-01" @default.
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- W137431094 title "ENZYME REGULATION, METABOLIC RATE AND ACID-BASE STATE IN HIBERNATION" @default.
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- W137431094 doi "https://doi.org/10.1016/b978-0-08-024938-4.50032-x" @default.
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