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• W1423281036 abstract "Heavy and light chain variable regions from eight monoclonal Ab2 (anti-idiotypic) antibodies of the GAT antigen, a (Glu60 Ala30 Tyr10)n co-polymer, have been analyzed by direct mRNA sequencing. Three mAb2s were directed against private idiotopes and used various VH-D-JH and Vk-Jk combinations. By contrast, the five 'anti-public' mAb2 antibodies used a very restricted repertoire, including all gene segments. Interestingly, within their D regions, Glu-Glu-Tyr or Tyr-Tyr-Glu sequences were reminiscent of the original (GAT) antigen and may act as possible internal images. A striking observation was that two mAb2 antibodies shared the same V-D-J sequence although derived from separate fusions. As this D sequence, 33 nucleotides long, has not been described so far, it is suggested that it may be encoded by a new germ-line D gene, acting as a crucial regulatory element in a GAT germ-line idiotypic network. An alternative model that may lead to the construction of this D segment by 'odd' rearrangements from pre-existing already reported sequences is also presented." @default.
• W1423281036 created "2016-06-24" @default.
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• W1423281036 date "1985-12-01" @default.
• W1423281036 modified "2023-10-18" @default.
• W1423281036 title "The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system." @default.
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• W1423281036 doi "https://doi.org/10.1002/j.1460-2075.1985.tb04135.x" @default.
• W1423281036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/554718" @default.
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• W1423281036 hasPublicationYear "1985" @default.
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