Matches in SemOpenAlex for { <https://semopenalex.org/work/W1487637701> ?p ?o ?g. }
- W1487637701 abstract "Abstract Autoradiographic studies have revealed that stimulation of rabbit spleen lymphocytes by various ConA doses involves two subpopulations responding successively when ConA concentration rises from 0.5 to 5 μg/ml. Equilibrium density sedimentation analysis of DNA replicated in the presence of BUdR is performed after stimulation by these different ConA concentrations. It is shown that at optimal doses to which each of these subpopulations responds, profiles of sedimentation correspond to a normal replication followed by cellular division and a second round of replication. After stimulation by minimal doses, sedimentation profiles indicate a discontinuous process of replication in which initiating events are numerous, but elongations partially blocked. This pattern suggests that the number of stimuli necessary to produce elongations is higher than that necessary to initiate replication. Comparison with effects produced by drugs like FUdR or HU on replication in continuous cultures suggests also that DNA synthesis in lymphocytes cultures could be regulated by a precise balance between stimulating and inhibiting factors. Finally equilibrium density analysis supports the autoradiographic finding that the duration of the S phase varies with the doses of ConA used. Different problems concerning replication in lymphocytes are discussed." @default.
- W1487637701 created "2016-06-24" @default.
- W1487637701 creator A5051685188 @default.
- W1487637701 creator A5061643246 @default.
- W1487637701 date "1976-08-01" @default.
- W1487637701 modified "2023-09-27" @default.
- W1487637701 title "DNA synthesis in rabbit spleen cell populations stimulated by various doses of Concanavalin A" @default.
- W1487637701 cites W1480244705 @default.
- W1487637701 cites W1501691462 @default.
- W1487637701 cites W1529675428 @default.
- W1487637701 cites W1567715859 @default.
- W1487637701 cites W1568881662 @default.
- W1487637701 cites W1568979214 @default.
- W1487637701 cites W1583435046 @default.
- W1487637701 cites W1591622763 @default.
- W1487637701 cites W1596167708 @default.
- W1487637701 cites W1605662436 @default.
- W1487637701 cites W1963950100 @default.
- W1487637701 cites W1966270194 @default.
- W1487637701 cites W1974929788 @default.
- W1487637701 cites W1979952535 @default.
- W1487637701 cites W1983146903 @default.
- W1487637701 cites W1987923121 @default.
- W1487637701 cites W1991004027 @default.
- W1487637701 cites W2011474487 @default.
- W1487637701 cites W2013273027 @default.
- W1487637701 cites W2013840708 @default.
- W1487637701 cites W2016015005 @default.
- W1487637701 cites W2027168332 @default.
- W1487637701 cites W2031639093 @default.
- W1487637701 cites W2034494883 @default.
- W1487637701 cites W2036793003 @default.
- W1487637701 cites W2046670528 @default.
- W1487637701 cites W2065498086 @default.
- W1487637701 cites W2066401248 @default.
- W1487637701 cites W2068796373 @default.
- W1487637701 cites W2070379577 @default.
- W1487637701 cites W2075355651 @default.
- W1487637701 cites W2075375430 @default.
- W1487637701 cites W2093988477 @default.
- W1487637701 cites W2116379492 @default.
- W1487637701 cites W2140719015 @default.
- W1487637701 cites W2205734451 @default.
- W1487637701 cites W2001671252 @default.
- W1487637701 doi "https://doi.org/10.1016/0014-4827(76)90416-x" @default.
- W1487637701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/954868" @default.
- W1487637701 hasPublicationYear "1976" @default.
- W1487637701 type Work @default.
- W1487637701 sameAs 1487637701 @default.
- W1487637701 citedByCount "6" @default.
- W1487637701 crossrefType "journal-article" @default.
- W1487637701 hasAuthorship W1487637701A5051685188 @default.
- W1487637701 hasAuthorship W1487637701A5061643246 @default.
- W1487637701 hasConcept C12554922 @default.
- W1487637701 hasConcept C12590798 @default.
- W1487637701 hasConcept C134018914 @default.
- W1487637701 hasConcept C1491633281 @default.
- W1487637701 hasConcept C153911025 @default.
- W1487637701 hasConcept C159047783 @default.
- W1487637701 hasConcept C19869320 @default.
- W1487637701 hasConcept C202751555 @default.
- W1487637701 hasConcept C203014093 @default.
- W1487637701 hasConcept C24998067 @default.
- W1487637701 hasConcept C2777108182 @default.
- W1487637701 hasConcept C2780931953 @default.
- W1487637701 hasConcept C552990157 @default.
- W1487637701 hasConcept C55493867 @default.
- W1487637701 hasConcept C64241487 @default.
- W1487637701 hasConcept C73573662 @default.
- W1487637701 hasConcept C85813293 @default.
- W1487637701 hasConcept C86803240 @default.
- W1487637701 hasConcept C95444343 @default.
- W1487637701 hasConceptScore W1487637701C12554922 @default.
- W1487637701 hasConceptScore W1487637701C12590798 @default.
- W1487637701 hasConceptScore W1487637701C134018914 @default.
- W1487637701 hasConceptScore W1487637701C1491633281 @default.
- W1487637701 hasConceptScore W1487637701C153911025 @default.
- W1487637701 hasConceptScore W1487637701C159047783 @default.
- W1487637701 hasConceptScore W1487637701C19869320 @default.
- W1487637701 hasConceptScore W1487637701C202751555 @default.
- W1487637701 hasConceptScore W1487637701C203014093 @default.
- W1487637701 hasConceptScore W1487637701C24998067 @default.
- W1487637701 hasConceptScore W1487637701C2777108182 @default.
- W1487637701 hasConceptScore W1487637701C2780931953 @default.
- W1487637701 hasConceptScore W1487637701C552990157 @default.
- W1487637701 hasConceptScore W1487637701C55493867 @default.
- W1487637701 hasConceptScore W1487637701C64241487 @default.
- W1487637701 hasConceptScore W1487637701C73573662 @default.
- W1487637701 hasConceptScore W1487637701C85813293 @default.
- W1487637701 hasConceptScore W1487637701C86803240 @default.
- W1487637701 hasConceptScore W1487637701C95444343 @default.
- W1487637701 hasLocation W14876377011 @default.
- W1487637701 hasLocation W14876377012 @default.
- W1487637701 hasOpenAccess W1487637701 @default.
- W1487637701 hasPrimaryLocation W14876377011 @default.
- W1487637701 hasRelatedWork W1967426677 @default.
- W1487637701 hasRelatedWork W1969435306 @default.
- W1487637701 hasRelatedWork W2007662494 @default.
- W1487637701 hasRelatedWork W2019267930 @default.
- W1487637701 hasRelatedWork W2033478241 @default.