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• W1488895831 abstract "This chapter focuses on the transmissible spongiform encephalopathies (TSE) of man and animals. Scrapie, Creutzfeldt–Jakob disease (CJD), Gerstmann–Straussler–Sheinker (GSS) syndrome, and related diseases of mink, mule deer, and elk are classified as the transmissible degenerative encephalopathies. Creutzfeldt–Jakob disease is a progressive dementia with clinical signs suggesting the dysfunction of the cerebellum, basal ganglia, and lower motor neurons. It is associated with gradual mental deterioration, leading to dementia and confusion and a progressive impairment of motor function. The incidence of CJD-related disease in humans is remarkably constant at 0.5–1 cases per million of population per year throughout the world and so is not linked to the incidence of any of the animal diseases. This low incidence casts doubt on the role of infection in its propagation within the population. The neuroligical lesions in bovine spongiform encephalopathy (BSE)-affected cow brains are virtually identical to those found in scrapie-affected sheep and include the spongiform change, which gives BSE its name. From its clinical and neuropathological signs, BSE was immediately suspected to belong to the scrapie family of transmissible spongiform encephalopathies. Transmissions to the mice of spongiform encephalopathy from six species that have been experimentally or naturally infected with BSE have given similar results to direct BSE transmissions from cattle." @default.
• W1488895831 created "2016-06-24" @default.
• W1488895831 creator A5088488998 @default.
• W1488895831 date "1998-01-01" @default.
• W1488895831 modified "2023-10-14" @default.
• W1488895831 title "16 Transmissible Spongiform Encephalopathies Of Man And Animals" @default.
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• W1488895831 doi "https://doi.org/10.1016/s1874-5326(07)80040-8" @default.
• W1488895831 hasPublicationYear "1998" @default.
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