FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1493175714> ?p ?o ?g. }

• W1493175714 endingPage "3087" @default.
• W1493175714 startingPage "3079" @default.
• W1493175714 abstract "Abstract We investigated the consequences of altering the form and valence of defined autodeterminants on the initiation and spreading of experimentally induced La/Ro autoimmunity. Anti-La and Ro (SS-A) Ab responses were monitored following immunization of healthy mice with defined immunodominant and subdominant T cell determinants of the La (SS-B) autoantigen synthesized as either monomeric or multiple antigenic (MAP) peptides. Abs to mouse La (mLa) developed faster and were of higher titer in mice immunized with the subdominant mLa25–44 MAP compared with mice immunized with the 25–44 monomer. Rapid intermolecular spreading of the autoimmune response to 60-kDa Ro was observed in AKR/J mice immunized with mLa25–44 MAP, but not in mice immunized repeatedly with monomeric peptide. A/J mice immunized and boosted with the known tolerogenic mLa287–301 determinant delivered as monomeric peptide failed to develop Abs to either intact mLa or mLa287–301 peptide. However, immunization with the multivalent mLa287–301 peptide led to the rapid production of high titer mLa autoantibodies associated with a proliferative T cell response to the mLa287–301 peptide. The data suggested that the enhanced immunogenicity of MAPs was not due to augmented Ag presentation or T cell stimulation. However, MAP-, but not monomer peptide-, containing immune complexes were potent substrates for Ab-dependent fixation of complement. These results demonstrate that the form of Ag responsible for inducing autoimmunity can profoundly influence the nature and magnitude of the immune response. Thus, molecular mimicry of tolerogenic and nontolerogenic self determinants might trigger autoimmunity under conditions of altered valence." @default.
• W1493175714 created "2016-06-24" @default.
• W1493175714 creator A5020039064 @default.
• W1493175714 creator A5023421955 @default.
• W1493175714 creator A5023848988 @default.
• W1493175714 creator A5031774873 @default.
• W1493175714 creator A5038670464 @default.
• W1493175714 creator A5045283443 @default.
• W1493175714 creator A5068597140 @default.
• W1493175714 creator A5084905252 @default.
• W1493175714 date "1999-03-01" @default.
• W1493175714 modified "2023-10-18" @default.
• W1493175714 title "Induction of Autoimmunity by Multivalent Immunodominant and Subdominant T Cell Determinants of La (SS-B)" @default.
• W1493175714 cites W1485596855 @default.
• W1493175714 cites W1498384534 @default.
• W1493175714 cites W1507586759 @default.
• W1493175714 cites W1510076901 @default.
• W1493175714 cites W1561796980 @default.
• W1493175714 cites W1582828290 @default.
• W1493175714 cites W1595494219 @default.
• W1493175714 cites W1654343738 @default.
• W1493175714 cites W1930246758 @default.
• W1493175714 cites W1976046500 @default.
• W1493175714 cites W1987556954 @default.
• W1493175714 cites W1996106388 @default.
• W1493175714 cites W1998388634 @default.
• W1493175714 cites W1998953208 @default.
• W1493175714 cites W2011658568 @default.
• W1493175714 cites W2013278989 @default.
• W1493175714 cites W2023466758 @default.
• W1493175714 cites W2028744022 @default.
• W1493175714 cites W2030764175 @default.
• W1493175714 cites W2033316041 @default.
• W1493175714 cites W2036178205 @default.
• W1493175714 cites W2039117471 @default.
• W1493175714 cites W2040589224 @default.
• W1493175714 cites W2043761376 @default.
• W1493175714 cites W2043837690 @default.
• W1493175714 cites W2044316391 @default.
• W1493175714 cites W2047552773 @default.
• W1493175714 cites W2052438035 @default.
• W1493175714 cites W2057581357 @default.
• W1493175714 cites W2058336420 @default.
• W1493175714 cites W2062082512 @default.
• W1493175714 cites W2067533631 @default.
• W1493175714 cites W2073315938 @default.
• W1493175714 cites W2073579100 @default.
• W1493175714 cites W2084093106 @default.
• W1493175714 cites W2091951610 @default.
• W1493175714 cites W2103976992 @default.
• W1493175714 cites W2112249032 @default.
• W1493175714 cites W2120887760 @default.
• W1493175714 cites W2127800073 @default.
• W1493175714 cites W2146185164 @default.
• W1493175714 cites W2159134769 @default.
• W1493175714 cites W2169466938 @default.
• W1493175714 cites W2169956921 @default.
• W1493175714 cites W2179629400 @default.
• W1493175714 doi "https://doi.org/10.4049/jimmunol.162.5.3079" @default.
• W1493175714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10072561" @default.
• W1493175714 hasPublicationYear "1999" @default.
• W1493175714 type Work @default.
• W1493175714 sameAs 1493175714 @default.
• W1493175714 citedByCount "24" @default.
• W1493175714 countsByYear W14931757142012 @default.
• W1493175714 countsByYear W14931757142014 @default.
• W1493175714 countsByYear W14931757142015 @default.
• W1493175714 countsByYear W14931757142016 @default.
• W1493175714 countsByYear W14931757142017 @default.
• W1493175714 crossrefType "journal-article" @default.
• W1493175714 hasAuthorship W1493175714A5020039064 @default.
• W1493175714 hasAuthorship W1493175714A5023421955 @default.
• W1493175714 hasAuthorship W1493175714A5023848988 @default.
• W1493175714 hasAuthorship W1493175714A5031774873 @default.
• W1493175714 hasAuthorship W1493175714A5038670464 @default.
• W1493175714 hasAuthorship W1493175714A5045283443 @default.
• W1493175714 hasAuthorship W1493175714A5068597140 @default.
• W1493175714 hasAuthorship W1493175714A5084905252 @default.
• W1493175714 hasBestOaLocation W14931757141 @default.
• W1493175714 hasConcept C147483822 @default.
• W1493175714 hasConcept C153911025 @default.
• W1493175714 hasConcept C159654299 @default.
• W1493175714 hasConcept C185592680 @default.
• W1493175714 hasConcept C203014093 @default.
• W1493175714 hasConcept C2776090121 @default.
• W1493175714 hasConcept C2778886782 @default.
• W1493175714 hasConcept C2779281246 @default.
• W1493175714 hasConcept C2780130043 @default.
• W1493175714 hasConcept C2780868878 @default.
• W1493175714 hasConcept C32611913 @default.
• W1493175714 hasConcept C55493867 @default.
• W1493175714 hasConcept C86803240 @default.
• W1493175714 hasConcept C8891405 @default.
• W1493175714 hasConceptScore W1493175714C147483822 @default.
• W1493175714 hasConceptScore W1493175714C153911025 @default.
• W1493175714 hasConceptScore W1493175714C159654299 @default.
• W1493175714 hasConceptScore W1493175714C185592680 @default.
• W1493175714 hasConceptScore W1493175714C203014093 @default.

• next