Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501926866> ?p ?o ?g. }
- W1501926866 endingPage "174" @default.
- W1501926866 startingPage "162" @default.
- W1501926866 abstract "Integrins are expressed in tumor cells and tumor endothelial cells, and likely play important roles in glioma angiogenesis and invasion. We investigated the anti‐glioma mechanisms of cilengitide ( EMD121974 ), an αvβ3 integrin inhibitor, utilizing the novel invasive glioma models, J3T‐1 and J3T‐2 . Immunohistochemical staining of cells in culture and brain tumors in rats revealed positive αvβ3 integrin expression in J3T ‐2 cells and tumor endothelial cells, but not in J3T ‐1 cells. Established J3T ‐1 and J3T ‐2 orthotopic gliomas in athymic rats were treated with cilengitide or solvent. J3T ‐1 gliomas showed perivascular tumor cluster formation and angiogenesis, while J3T ‐2 gliomas showed diffuse single‐cell infiltration without obvious angiogenesis. Cilengitide treatment resulted in a significantly decreased diameter of the J3T ‐1 tumor vessel clusters and its core vessels when compared with controls, while an anti‐invasive effect was shown in the J3T ‐2 glioma with a significant reduction of diffuse cell infiltration around the tumor center. The survival of cilengitide‐treated mice harboring J3T ‐1 tumors was significantly longer than that of control animals (median survival: 57.5 days and 31.8 days, respectively, P < 0.005), while cilengitide had no effect on the survival of mice with J3T ‐2 tumors (median survival: 48.9 days and 48.5, P = 0.69). Our results indicate that cilengitide exerts a phenotypic anti‐tumor effect by inhibiting angiogenesis and glioma cell invasion. These two mechanisms are clearly shown by the experimental treatment of two different animal invasive glioma models." @default.
- W1501926866 created "2016-06-24" @default.
- W1501926866 creator A5004595871 @default.
- W1501926866 creator A5020419482 @default.
- W1501926866 creator A5032713958 @default.
- W1501926866 creator A5033917464 @default.
- W1501926866 creator A5041131555 @default.
- W1501926866 creator A5047350203 @default.
- W1501926866 creator A5059538840 @default.
- W1501926866 creator A5065128406 @default.
- W1501926866 creator A5080566517 @default.
- W1501926866 creator A5087128686 @default.
- W1501926866 date "2012-09-19" @default.
- W1501926866 modified "2023-10-16" @default.
- W1501926866 title "Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models" @default.
- W1501926866 cites W1600721209 @default.
- W1501926866 cites W1976520103 @default.
- W1501926866 cites W1990824001 @default.
- W1501926866 cites W2001753204 @default.
- W1501926866 cites W2002727873 @default.
- W1501926866 cites W2014758132 @default.
- W1501926866 cites W2018016372 @default.
- W1501926866 cites W2025811635 @default.
- W1501926866 cites W2029773366 @default.
- W1501926866 cites W2036258190 @default.
- W1501926866 cites W2038949876 @default.
- W1501926866 cites W2039317622 @default.
- W1501926866 cites W2045488700 @default.
- W1501926866 cites W2058901785 @default.
- W1501926866 cites W2060751914 @default.
- W1501926866 cites W2064360454 @default.
- W1501926866 cites W2068124694 @default.
- W1501926866 cites W2072815621 @default.
- W1501926866 cites W2074409981 @default.
- W1501926866 cites W2074427147 @default.
- W1501926866 cites W2075306542 @default.
- W1501926866 cites W2080208032 @default.
- W1501926866 cites W2082800425 @default.
- W1501926866 cites W2086069051 @default.
- W1501926866 cites W2093783077 @default.
- W1501926866 cites W2096287682 @default.
- W1501926866 cites W2104605014 @default.
- W1501926866 cites W2115516828 @default.
- W1501926866 cites W2127745545 @default.
- W1501926866 cites W2131480590 @default.
- W1501926866 cites W2139304914 @default.
- W1501926866 cites W2139676810 @default.
- W1501926866 cites W2172837858 @default.
- W1501926866 cites W2398970429 @default.
- W1501926866 doi "https://doi.org/10.1111/j.1440-1789.2012.01344.x" @default.
- W1501926866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4861321" @default.
- W1501926866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22989076" @default.
- W1501926866 hasPublicationYear "2012" @default.
- W1501926866 type Work @default.
- W1501926866 sameAs 1501926866 @default.
- W1501926866 citedByCount "19" @default.
- W1501926866 countsByYear W15019268662013 @default.
- W1501926866 countsByYear W15019268662014 @default.
- W1501926866 countsByYear W15019268662015 @default.
- W1501926866 countsByYear W15019268662016 @default.
- W1501926866 countsByYear W15019268662017 @default.
- W1501926866 countsByYear W15019268662018 @default.
- W1501926866 countsByYear W15019268662019 @default.
- W1501926866 countsByYear W15019268662023 @default.
- W1501926866 crossrefType "journal-article" @default.
- W1501926866 hasAuthorship W1501926866A5004595871 @default.
- W1501926866 hasAuthorship W1501926866A5020419482 @default.
- W1501926866 hasAuthorship W1501926866A5032713958 @default.
- W1501926866 hasAuthorship W1501926866A5033917464 @default.
- W1501926866 hasAuthorship W1501926866A5041131555 @default.
- W1501926866 hasAuthorship W1501926866A5047350203 @default.
- W1501926866 hasAuthorship W1501926866A5059538840 @default.
- W1501926866 hasAuthorship W1501926866A5065128406 @default.
- W1501926866 hasAuthorship W1501926866A5080566517 @default.
- W1501926866 hasAuthorship W1501926866A5087128686 @default.
- W1501926866 hasBestOaLocation W15019268662 @default.
- W1501926866 hasConcept C121332964 @default.
- W1501926866 hasConcept C121608353 @default.
- W1501926866 hasConcept C126322002 @default.
- W1501926866 hasConcept C142724271 @default.
- W1501926866 hasConcept C153400128 @default.
- W1501926866 hasConcept C170493617 @default.
- W1501926866 hasConcept C195687474 @default.
- W1501926866 hasConcept C204232928 @default.
- W1501926866 hasConcept C2776056115 @default.
- W1501926866 hasConcept C2778227246 @default.
- W1501926866 hasConcept C2779256057 @default.
- W1501926866 hasConcept C2780394083 @default.
- W1501926866 hasConcept C502942594 @default.
- W1501926866 hasConcept C71924100 @default.
- W1501926866 hasConcept C97355855 @default.
- W1501926866 hasConceptScore W1501926866C121332964 @default.
- W1501926866 hasConceptScore W1501926866C121608353 @default.
- W1501926866 hasConceptScore W1501926866C126322002 @default.
- W1501926866 hasConceptScore W1501926866C142724271 @default.
- W1501926866 hasConceptScore W1501926866C153400128 @default.
- W1501926866 hasConceptScore W1501926866C170493617 @default.
- W1501926866 hasConceptScore W1501926866C195687474 @default.