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• W1521036779 abstract "Glucagon-like peptide-1 (GLP-1) is an incretin hormone, and its analogs have been reported effective in ischemic or non-ischemic heart diseases as well as diabetes mellitus. Dipeptidyl-peptidase IV (DPP-IV) inhibitors that reduce GLP-1 degradation are considered cardioprotective for such pathophysiological states. Since heart failure (HF) is linked to impaired glucose tolerance, we aimed to clarify the effects of DPP-IV inhibitors on HF using pressure-overload hypertrophy model mice (male C57BL6 at 8 weeks of age). Cardiac hypertrophy and HF were induced by transverse aortic constriction (TAC) in a group of mice that were randomised to 2 subgroups, one of which received oral drinking water containing vildagliptin (0.2mg/ml) (TV), and the other received water only (TC). We also made 2 sham operation subgroups, one of which had the same vildagliptin dissolution (SV) and the other was a control (SC). TV had better survival curve than TC (67% vs. 38%, respectively) 14 days after TAC operation. The ratio of heart weight to body weight (mg/g) (6.12 ± 0.69 (SEM) in all TAC vs. 4.99 ± 0.17 in SC, p" @default.
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• W1521036779 date "2010-11-23" @default.
• W1521036779 modified "2023-09-25" @default.
• W1521036779 title "Abstract 19013: Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model" @default.
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