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- W1556680226 abstract "It is well-known that endocrine systems have a major effect on the functioning of the cardiovascular system. Hyperadrenalism and both growth hormone (GH) excess and deficiency are associated with increased cardiovascular morbidity and mortality. Many of the clinical and biochemical features of the metabolic syndrome are common to GH deficiency and hyperadrenalism. This is perhaps unsurprising given the multiple effects these hormones have on intermediate metabolism, blood pressure and body composition. Local regulation of cortisol function at a tissue level through the action of 11β-hydroxysteroid dehydrogenase (11HSD1) may also affect the risk of metabolic syndrome. Inhibitors of 11HSD1 and glucocorticoid receptor antagonists are being developed by the pharmaceutical industry for their potential to treat insulin resistance and other aspects of metabolic syndrome. Similarly there have been trials of the use of GH in the treatment of obesity; however although GH treatment leads to a reduction in body weight, this is no greater than can be achieved through diet alone and metabolic health does not seem to improve, at least in the short term." @default.
- W1556680226 created "2016-06-24" @default.
- W1556680226 creator A5004472997 @default.
- W1556680226 creator A5019428645 @default.
- W1556680226 date "2011-06-10" @default.
- W1556680226 modified "2023-10-18" @default.
- W1556680226 title "Endocrine Aspects of the Metabolic Syndrome" @default.
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