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• W1569021327 endingPage "1126" @default.
• W1569021327 startingPage "1117" @default.
• W1569021327 abstract "Alginate-encapsulated HepG2 cells cultured in microgravity have the potential to serve as the cellular component of a bioartificial liver. This study investigates their performance in normal and liver failure (LF) human plasma over 6–8 h in a fluidized bed bioreactor. After 8 days of microgravity culture, beads containing 1.5 × 109 cells were perfused for up to 8 h at 48 mL/min with 300 mL of plasma. After exposure to 90% LF plasma, vital dye staining showed maintained cell viability, while a 7% increase in lactate dehydrogenase activity indicated minimal cell damage. Glucose consumption, lactate production, and a 4.3-fold linear increase in alpha-fetoprotein levels were observed. Detoxificatory function was demonstrated by quantification of bilirubin conjugation, urea synthesis, and Cyp450 1A activity. These data show that in LF plasma, alginate-encapsulated HepG2 cells can maintain viability, and metabolic, synthetic, and detoxificatory activities, indicating that the system can be scaled-up to form the biological component of a bioartificial liver." @default.
• W1569021327 created "2016-06-24" @default.
• W1569021327 creator A5000254576 @default.
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• W1569021327 date "2009-12-01" @default.
• W1569021327 modified "2023-10-10" @default.
• W1569021327 title "Alginate-encapsulated HepG2 Cells in a Fluidized Bed Bioreactor Maintain Function in Human Liver Failure Plasma" @default.
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• W1569021327 doi "https://doi.org/10.1111/j.1525-1594.2009.00821.x" @default.
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