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- W1570688778 abstract "Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health." @default.
- W1570688778 created "2016-06-24" @default.
- W1570688778 creator A5013405117 @default.
- W1570688778 creator A5017361278 @default.
- W1570688778 creator A5050160272 @default.
- W1570688778 creator A5077642215 @default.
- W1570688778 date "2015-01-01" @default.
- W1570688778 modified "2023-09-26" @default.
- W1570688778 title "The Role of Cardiolipin in Cardiovascular Health" @default.
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