Matches in SemOpenAlex for { <https://semopenalex.org/work/W1606892626> ?p ?o ?g. }
- W1606892626 endingPage "1994" @default.
- W1606892626 startingPage "1973" @default.
- W1606892626 abstract "The halophilic γ-proteobacterium Halomonas elongata DSM 2581(T) thrives at high salinity by synthesizing and accumulating the compatible solute ectoine. Ectoine levels are highly regulated according to external salt levels but the overall picture of its metabolism and control is not well understood. Apart from its critical role in cell adaptation to halophilic environments, ectoine can be used as a stabilizer for enzymes and as a cell protectant in skin and health care applications and is thus produced annually on a scale of tons in an industrial process using H. elongata as producer strain. This paper presents the complete genome sequence of H. elongata (4,061,296 bp) and includes experiments and analysis identifying and characterizing the entire ectoine metabolism, including a newly discovered pathway for ectoine degradation and its cyclic connection to ectoine synthesis. The degradation of ectoine (doe) proceeds via hydrolysis of ectoine (DoeA) to Nα-acetyl-L-2,4-diaminobutyric acid, followed by deacetylation to diaminobutyric acid (DoeB). In H. elongata, diaminobutyric acid can either flow off to aspartate or re-enter the ectoine synthesis pathway, forming a cycle of ectoine synthesis and degradation. Genome comparison revealed that the ectoine degradation pathway exists predominantly in non-halophilic bacteria unable to synthesize ectoine. Based on the resulting genetic and biochemical data, a metabolic flux model of ectoine metabolism was derived that can be used to understand the way H. elongata survives under varying salt stresses and that provides a basis for a model-driven improvement of industrial ectoine production." @default.
- W1606892626 created "2016-06-24" @default.
- W1606892626 creator A5000733670 @default.
- W1606892626 creator A5011689107 @default.
- W1606892626 creator A5013221314 @default.
- W1606892626 creator A5024866710 @default.
- W1606892626 creator A5050246403 @default.
- W1606892626 creator A5060035917 @default.
- W1606892626 creator A5065526551 @default.
- W1606892626 creator A5067309126 @default.
- W1606892626 creator A5077404586 @default.
- W1606892626 creator A5078757245 @default.
- W1606892626 creator A5087855826 @default.
- W1606892626 creator A5088865524 @default.
- W1606892626 date "2010-09-16" @default.
- W1606892626 modified "2023-10-14" @default.
- W1606892626 title "A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581T" @default.
- W1606892626 cites W1492989453 @default.
- W1606892626 cites W1498046209 @default.
- W1606892626 cites W1516878686 @default.
- W1606892626 cites W1518290678 @default.
- W1606892626 cites W1580982499 @default.
- W1606892626 cites W1918140755 @default.
- W1606892626 cites W1963957860 @default.
- W1606892626 cites W1965448029 @default.
- W1606892626 cites W1969186306 @default.
- W1606892626 cites W1969253588 @default.
- W1606892626 cites W1970129922 @default.
- W1606892626 cites W1970870670 @default.
- W1606892626 cites W1974134170 @default.
- W1606892626 cites W1976935537 @default.
- W1606892626 cites W1977371069 @default.
- W1606892626 cites W1978289664 @default.
- W1606892626 cites W1979318375 @default.
- W1606892626 cites W1982682366 @default.
- W1606892626 cites W1983548091 @default.
- W1606892626 cites W1983812869 @default.
- W1606892626 cites W1985048417 @default.
- W1606892626 cites W1987675286 @default.
- W1606892626 cites W1993032194 @default.
- W1606892626 cites W1995238008 @default.
- W1606892626 cites W1998591058 @default.
- W1606892626 cites W2003813384 @default.
- W1606892626 cites W2005989563 @default.
- W1606892626 cites W2007135866 @default.
- W1606892626 cites W2011268373 @default.
- W1606892626 cites W2014870043 @default.
- W1606892626 cites W2015897256 @default.
- W1606892626 cites W2016165178 @default.
- W1606892626 cites W2016405093 @default.
- W1606892626 cites W2016769150 @default.
- W1606892626 cites W2016889496 @default.
- W1606892626 cites W2019631913 @default.
- W1606892626 cites W2023542711 @default.
- W1606892626 cites W2027229485 @default.
- W1606892626 cites W2034337315 @default.
- W1606892626 cites W2038124483 @default.
- W1606892626 cites W2039484307 @default.
- W1606892626 cites W2040459817 @default.
- W1606892626 cites W2042998656 @default.
- W1606892626 cites W2045843097 @default.
- W1606892626 cites W2053129511 @default.
- W1606892626 cites W2053150867 @default.
- W1606892626 cites W2054878415 @default.
- W1606892626 cites W2057470797 @default.
- W1606892626 cites W2057487010 @default.
- W1606892626 cites W2057808619 @default.
- W1606892626 cites W2058991361 @default.
- W1606892626 cites W2059163774 @default.
- W1606892626 cites W2070639556 @default.
- W1606892626 cites W2071797918 @default.
- W1606892626 cites W2073481152 @default.
- W1606892626 cites W2084222125 @default.
- W1606892626 cites W2089225432 @default.
- W1606892626 cites W2090469348 @default.
- W1606892626 cites W2091168091 @default.
- W1606892626 cites W2094108808 @default.
- W1606892626 cites W2095724872 @default.
- W1606892626 cites W2095855112 @default.
- W1606892626 cites W2096215014 @default.
- W1606892626 cites W2097250648 @default.
- W1606892626 cites W2101269698 @default.
- W1606892626 cites W2104296423 @default.
- W1606892626 cites W2104635931 @default.
- W1606892626 cites W2105254342 @default.
- W1606892626 cites W2106069035 @default.
- W1606892626 cites W2106392733 @default.
- W1606892626 cites W2106814707 @default.
- W1606892626 cites W2107282968 @default.
- W1606892626 cites W2116895571 @default.
- W1606892626 cites W2117443107 @default.
- W1606892626 cites W2127660113 @default.
- W1606892626 cites W2128114769 @default.
- W1606892626 cites W2132926880 @default.
- W1606892626 cites W2133253129 @default.
- W1606892626 cites W2137562565 @default.
- W1606892626 cites W2139007168 @default.
- W1606892626 cites W2140994581 @default.