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- W1615491738 endingPage "1073" @default.
- W1615491738 startingPage "1059" @default.
- W1615491738 abstract "Benign prostatic hyperplasia (BPH) is a common disease among men and significantly impacts quality of life by causing lower urinary tract symptoms (LUTS). Current medical therapies are not always adequate in controlling LUTS or slowing disease progression, and there is unmet need for new effective therapeutic options.The authors review the standard current medical therapies for BPH which include the use of α-1 blockers, 5-α reductase inhibitors, combination therapy and PDE inhibitors. Following this, the authors then discuss new therapies that are currently undergoing preclinical and clinical investigation.Existing preclinical and clinical trials have highlighted many promising therapies to treat BPH. Further investigation with larger clinical trials is needed to establish these drugs as standard therapies. As the number of drugs in the arsenal against BPH continues to grow, providers and patients will have to engage in a discussion that weighs the risks and benefits of each therapy." @default.
- W1615491738 created "2016-06-24" @default.
- W1615491738 creator A5026172333 @default.
- W1615491738 creator A5035462377 @default.
- W1615491738 creator A5036848171 @default.
- W1615491738 creator A5088087067 @default.
- W1615491738 date "2015-05-18" @default.
- W1615491738 modified "2023-09-24" @default.
- W1615491738 title "A synopsis of drugs currently in preclinical and early clinical development for the treatment of benign prostatic hyperplasia" @default.
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- W1615491738 doi "https://doi.org/10.1517/13543784.2015.1048333" @default.
- W1615491738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25982036" @default.
- W1615491738 hasPublicationYear "2015" @default.