Matches in SemOpenAlex for { <https://semopenalex.org/work/W1723429543> ?p ?o ?g. }
- W1723429543 abstract "The mammalian X chromosome has a fascinating evolutionary history, which is intimately linked to that of the Y chromosome because both evolved in concert from identical chromosomes. Teasing apart the events of this evolution has been helped greatly by identifying similarities and differences between the X and Y and by comparing the sex chromosomes of different mammalian species. Comparison of the human X and Y with the sex chromosomes of exotic basal eutherian mammals (in particular, afrotherian representatives such as the elephant) has revealed extraordinary conservation of gross X gene order. Comparison with the sex chromosomes of the distantly related marsupial and monotreme mammals has proved remarkably valuable for identifying features of the X that are unique to eutherian mammals along with characteristics that have been conserved since before the marsupial/eutherian split approximately 150 Ma.Key Concepts: Therian (eutherian and marsupial) sex chromosomes evolved from a homologous pair of autosomes via a process of Y degradation after recombination with the X was suppressed.The therian sex chromosomes arose after divergence of monotremes but before the eutherian/marsupial split.Dosage compensation evolved in response to the loss of functional Y genes, which ultimately restored the balance of gene dosage from the single X in males and two X chromosomes in females.Because the Y is male specific, it bears genes important to male development and reproduction.Alleles on the single X in males are instantly open to selection, which is hypothesised to have resulted from an accumulation of testis genes on the X.Keywords:X chromosome;Y chromosome;evolution;dosage compensation;X chromosome inactivation" @default.
- W1723429543 created "2016-06-24" @default.
- W1723429543 creator A5072522439 @default.
- W1723429543 creator A5089371380 @default.
- W1723429543 date "2013-03-15" @default.
- W1723429543 modified "2023-10-18" @default.
- W1723429543 title "Evolution of the Mammalian X Chromosome" @default.
- W1723429543 cites W1499944371 @default.
- W1723429543 cites W1939885667 @default.
- W1723429543 cites W1980179472 @default.
- W1723429543 cites W1985512910 @default.
- W1723429543 cites W1985658425 @default.
- W1723429543 cites W1986163694 @default.
- W1723429543 cites W1992168356 @default.
- W1723429543 cites W1994084343 @default.
- W1723429543 cites W2017751411 @default.
- W1723429543 cites W2020958409 @default.
- W1723429543 cites W2027648691 @default.
- W1723429543 cites W2032431333 @default.
- W1723429543 cites W2033285403 @default.
- W1723429543 cites W2036164339 @default.
- W1723429543 cites W2036507321 @default.
- W1723429543 cites W2041737724 @default.
- W1723429543 cites W2043632023 @default.
- W1723429543 cites W2064147650 @default.
- W1723429543 cites W2078075583 @default.
- W1723429543 cites W2085422902 @default.
- W1723429543 cites W2086399711 @default.
- W1723429543 cites W2087323996 @default.
- W1723429543 cites W2093466316 @default.
- W1723429543 cites W2093778106 @default.
- W1723429543 cites W2099848129 @default.
- W1723429543 cites W2102619381 @default.
- W1723429543 cites W2109183032 @default.
- W1723429543 cites W2113289439 @default.
- W1723429543 cites W2115031948 @default.
- W1723429543 cites W2122152054 @default.
- W1723429543 cites W2123632351 @default.
- W1723429543 cites W2124511083 @default.
- W1723429543 cites W2126084304 @default.
- W1723429543 cites W2127093981 @default.
- W1723429543 cites W2130743364 @default.
- W1723429543 cites W2140803428 @default.
- W1723429543 cites W2141799932 @default.
- W1723429543 cites W2142602296 @default.
- W1723429543 cites W2143393835 @default.
- W1723429543 cites W2144012199 @default.
- W1723429543 cites W2155769045 @default.
- W1723429543 cites W2155932202 @default.
- W1723429543 cites W2157327468 @default.
- W1723429543 cites W2161865817 @default.
- W1723429543 cites W2162716521 @default.
- W1723429543 cites W2163220561 @default.
- W1723429543 cites W2164207497 @default.
- W1723429543 cites W2166619420 @default.
- W1723429543 cites W2171189056 @default.
- W1723429543 cites W4255745254 @default.
- W1723429543 cites W4293003414 @default.
- W1723429543 doi "https://doi.org/10.1002/9780470015902.a0020739.pub2" @default.
- W1723429543 hasPublicationYear "2013" @default.
- W1723429543 type Work @default.
- W1723429543 sameAs 1723429543 @default.
- W1723429543 citedByCount "1" @default.
- W1723429543 countsByYear W17234295432015 @default.
- W1723429543 crossrefType "reference-entry" @default.
- W1723429543 hasAuthorship W1723429543A5072522439 @default.
- W1723429543 hasAuthorship W1723429543A5089371380 @default.
- W1723429543 hasConcept C104317684 @default.
- W1723429543 hasConcept C134925867 @default.
- W1723429543 hasConcept C139690037 @default.
- W1723429543 hasConcept C2777042810 @default.
- W1723429543 hasConcept C2777322942 @default.
- W1723429543 hasConcept C2780246931 @default.
- W1723429543 hasConcept C2781202234 @default.
- W1723429543 hasConcept C30481170 @default.
- W1723429543 hasConcept C35158069 @default.
- W1723429543 hasConcept C41806617 @default.
- W1723429543 hasConcept C53226629 @default.
- W1723429543 hasConcept C54355233 @default.
- W1723429543 hasConcept C58642233 @default.
- W1723429543 hasConcept C64894306 @default.
- W1723429543 hasConcept C78458016 @default.
- W1723429543 hasConcept C86803240 @default.
- W1723429543 hasConcept C90856448 @default.
- W1723429543 hasConcept C92509807 @default.
- W1723429543 hasConceptScore W1723429543C104317684 @default.
- W1723429543 hasConceptScore W1723429543C134925867 @default.
- W1723429543 hasConceptScore W1723429543C139690037 @default.
- W1723429543 hasConceptScore W1723429543C2777042810 @default.
- W1723429543 hasConceptScore W1723429543C2777322942 @default.
- W1723429543 hasConceptScore W1723429543C2780246931 @default.
- W1723429543 hasConceptScore W1723429543C2781202234 @default.
- W1723429543 hasConceptScore W1723429543C30481170 @default.
- W1723429543 hasConceptScore W1723429543C35158069 @default.
- W1723429543 hasConceptScore W1723429543C41806617 @default.
- W1723429543 hasConceptScore W1723429543C53226629 @default.
- W1723429543 hasConceptScore W1723429543C54355233 @default.
- W1723429543 hasConceptScore W1723429543C58642233 @default.
- W1723429543 hasConceptScore W1723429543C64894306 @default.
- W1723429543 hasConceptScore W1723429543C78458016 @default.